Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.
Publication
, Journal Article
Hwang, SS; Boyle, TJ; Lyerly, HK; Cullen, BR
Published in: Science
July 5, 1991
Cells of the monocyte-macrophage lineage are targets for human immunodeficiency virus-1 (HIV-1) infection in vivo. However, many laboratory strains of HIV-1 that efficiently infect transformed T cell lines replicate poorly in macrophages. A 20-amino acid sequence from the macrophage-tropic BaL isolate of HIV-1 was sufficient to confer macrophage tropism on HTLV-IIIB, a T cell line--tropic isolate. This small sequence element is in the V3 loop, the envelope domain that is the principal neutralizing determinant of HIV-1. Thus, the V3 loop not only serves as a target of the host immune response but is also pivotal in determining HIV-1 tissue tropism.
Duke Scholars
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Published In
Science
DOI
ISSN
0036-8075
Publication Date
July 5, 1991
Volume
253
Issue
5015
Start / End Page
71 / 74
Location
United States
Related Subject Headings
- Viral Envelope Proteins
- Sequence Homology, Nucleic Acid
- Restriction Mapping
- Proviruses
- Mutation
- Molecular Sequence Data
- Haplorhini
- HIV-1
- Genes, env
- General Science & Technology
Citation
APA
Chicago
ICMJE
MLA
NLM
Hwang, S. S., Boyle, T. J., Lyerly, H. K., & Cullen, B. R. (1991). Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. Science, 253(5015), 71–74. https://doi.org/10.1126/science.1905842
Hwang, S. S., T. J. Boyle, H. K. Lyerly, and B. R. Cullen. “Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.” Science 253, no. 5015 (July 5, 1991): 71–74. https://doi.org/10.1126/science.1905842.
Hwang SS, Boyle TJ, Lyerly HK, Cullen BR. Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. Science. 1991 Jul 5;253(5015):71–4.
Hwang, S. S., et al. “Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.” Science, vol. 253, no. 5015, July 1991, pp. 71–74. Pubmed, doi:10.1126/science.1905842.
Hwang SS, Boyle TJ, Lyerly HK, Cullen BR. Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. Science. 1991 Jul 5;253(5015):71–74.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
July 5, 1991
Volume
253
Issue
5015
Start / End Page
71 / 74
Location
United States
Related Subject Headings
- Viral Envelope Proteins
- Sequence Homology, Nucleic Acid
- Restriction Mapping
- Proviruses
- Mutation
- Molecular Sequence Data
- Haplorhini
- HIV-1
- Genes, env
- General Science & Technology