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Evaluation of porcine-derived small intestine submucosa as a biodegradable graft for gastrointestinal healing.

Publication ,  Journal Article
de la Fuente, SG; Gottfried, MR; Lawson, DC; Harris, MB; Mantyh, CR; Pappas, TN
Published in: J Gastrointest Surg
January 2003

High-risk anastomoses in the gut may benefit from the application of a synthetic reinforcement to prevent an enteric leak. Recently a porcine-derived small intestine submucosa (SIS) was tested as a bioscaffold in a number of organ systems. The aim of this study was to evaluate the effectiveness of SIS in stimulating healing in the stomach. Twelve rats underwent surgical removal of a full-thickness gastric defect (1 cm) and subsequent repair with a double-layer patch of porcine-derived SIS. The graft was secured with interrupted sutures placed within 1 mm of the edge of the graft. After 21 days, the animals were killed and their stomachs harvested for histologic examination. Cross sections were processed for paraffin embedding and 4-micron sections were stained with hematoxylin and eosin. All animals survived, gained weight, and demonstrated no signs of peritonitis over the 3-week postoperative period. On postmortem examination, the defect was completely closed in all animals by granulation tissue and early fibrosis. Although most of the luminal surface of the grafted areas remained ulcerated, early regeneration of normal gastric mucosa was seen at the periphery of the defect. SIS may act as an effective scaffolding agent for intestinal mucosa and may offer protection in high-risk anastomoses.

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Published In

J Gastrointest Surg

DOI

ISSN

1091-255X

Publication Date

January 2003

Volume

7

Issue

1

Start / End Page

96 / 101

Location

Netherlands

Related Subject Headings

  • Wound Healing
  • Transplantation, Heterologous
  • Tissue Engineering
  • Swine
  • Surgery
  • Stomach
  • Rats, Wistar
  • Rats
  • Intestinal Mucosa
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
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de la Fuente, S. G., Gottfried, M. R., Lawson, D. C., Harris, M. B., Mantyh, C. R., & Pappas, T. N. (2003). Evaluation of porcine-derived small intestine submucosa as a biodegradable graft for gastrointestinal healing. J Gastrointest Surg, 7(1), 96–101. https://doi.org/10.1016/S1091-255X(02)00050-1
Fuente, Sebastian G. de la, Marcia R. Gottfried, D Curtis Lawson, Mary B. Harris, Christopher R. Mantyh, and Theodore N. Pappas. “Evaluation of porcine-derived small intestine submucosa as a biodegradable graft for gastrointestinal healing.J Gastrointest Surg 7, no. 1 (January 2003): 96–101. https://doi.org/10.1016/S1091-255X(02)00050-1.
de la Fuente SG, Gottfried MR, Lawson DC, Harris MB, Mantyh CR, Pappas TN. Evaluation of porcine-derived small intestine submucosa as a biodegradable graft for gastrointestinal healing. J Gastrointest Surg. 2003 Jan;7(1):96–101.
de la Fuente, Sebastian G., et al. “Evaluation of porcine-derived small intestine submucosa as a biodegradable graft for gastrointestinal healing.J Gastrointest Surg, vol. 7, no. 1, Jan. 2003, pp. 96–101. Pubmed, doi:10.1016/S1091-255X(02)00050-1.
de la Fuente SG, Gottfried MR, Lawson DC, Harris MB, Mantyh CR, Pappas TN. Evaluation of porcine-derived small intestine submucosa as a biodegradable graft for gastrointestinal healing. J Gastrointest Surg. 2003 Jan;7(1):96–101.
Journal cover image

Published In

J Gastrointest Surg

DOI

ISSN

1091-255X

Publication Date

January 2003

Volume

7

Issue

1

Start / End Page

96 / 101

Location

Netherlands

Related Subject Headings

  • Wound Healing
  • Transplantation, Heterologous
  • Tissue Engineering
  • Swine
  • Surgery
  • Stomach
  • Rats, Wistar
  • Rats
  • Intestinal Mucosa
  • Animals