Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene.
Publication
, Journal Article
Milano, CA; Allen, LF; Dolber, PC; Johnson, TD; Rockman, HA; Bond, RA; Lefkowitz, RJ
Published in: J Thorac Cardiovasc Surg
February 1995
Transgenic mice with intense cardiac expression of a human beta-adrenergic receptor gene were engineered and shown to display marked improvements in baseline myocardial and left ventricular function. Heart/body weight ratios and histologic appearance were not found to be significantly altered, suggesting that receptor gene expression did not induce pathologic changes. Given the substantial reduction in beta-adrenergic receptor density and resultant reduction in inotropic responsiveness observed in chronic heart failure, these findings represent a novel approach for increasing myocardial function with important clinical implications.
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Published In
J Thorac Cardiovasc Surg
DOI
ISSN
0022-5223
Publication Date
February 1995
Volume
109
Issue
2
Start / End Page
236 / 241
Location
United States
Related Subject Headings
- Ventricular Function, Left
- Respiratory System
- Receptors, Adrenergic, beta-2
- Organ Size
- Myosins
- Myocardium
- Myocardial Contraction
- Mice, Transgenic
- Mice
- Male
Citation
APA
Chicago
ICMJE
MLA
NLM
Milano, C. A., Allen, L. F., Dolber, P. C., Johnson, T. D., Rockman, H. A., Bond, R. A., & Lefkowitz, R. J. (1995). Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene. J Thorac Cardiovasc Surg, 109(2), 236–241. https://doi.org/10.1016/s0022-5223(95)70384-5
Milano, C. A., L. F. Allen, P. C. Dolber, T. D. Johnson, H. A. Rockman, R. A. Bond, and R. J. Lefkowitz. “Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene.” J Thorac Cardiovasc Surg 109, no. 2 (February 1995): 236–41. https://doi.org/10.1016/s0022-5223(95)70384-5.
Milano CA, Allen LF, Dolber PC, Johnson TD, Rockman HA, Bond RA, et al. Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene. J Thorac Cardiovasc Surg. 1995 Feb;109(2):236–41.
Milano, C. A., et al. “Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene.” J Thorac Cardiovasc Surg, vol. 109, no. 2, Feb. 1995, pp. 236–41. Pubmed, doi:10.1016/s0022-5223(95)70384-5.
Milano CA, Allen LF, Dolber PC, Johnson TD, Rockman HA, Bond RA, Lefkowitz RJ. Marked enhancement in myocardial function resulting from overexpression of a human beta-adrenergic receptor gene. J Thorac Cardiovasc Surg. 1995 Feb;109(2):236–241.
Published In
J Thorac Cardiovasc Surg
DOI
ISSN
0022-5223
Publication Date
February 1995
Volume
109
Issue
2
Start / End Page
236 / 241
Location
United States
Related Subject Headings
- Ventricular Function, Left
- Respiratory System
- Receptors, Adrenergic, beta-2
- Organ Size
- Myosins
- Myocardium
- Myocardial Contraction
- Mice, Transgenic
- Mice
- Male