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The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract.

Publication ,  Journal Article
McGhee, JR; Xu-Amano, J; Miller, CJ; Jackson, RJ; Fujihashi, K; Staats, HF; Kiyono, H
Published in: Reprod Fertil Dev
1994

The realization that induction of immune responses at mucosal surfaces may prevent colonization, invasion or dissemination of pathogenic microorganisms has spurred intensive efforts to develop vaccines which elicit effective mucosal immunity. In this paper, recent results are discussed for mice given cholera toxin as both an immunogen and as an adjuvant for inducing both humoral and gastrointestinal mucosal immune responses. Oral administration of cholera toxin alone or with a co-administered protein vaccine tetanus toxoid induces a strong T helper type 2 (TH2) cell response in both Peyer's patches and spleen. Both serum IgG and secretory IgA antibodies specific for cholera toxin or for the co-administered protein tetanus toxoid were induced. When administered parentally, however, no mucosal antibody responses were evident and a mixed TH1- and TH2-type CD4+ T cell response was noted in the spleen. Various vectors are being employed in an effort not only to induce mucosal immune responses but also to direct the response to a TH1-type response, thought to promote strong cell-mediated immune responses, or to a TH2-type response for maximum B cell antibody responses. The ability to manipulate the TH cell responses may provide a more rational approach for the design of vaccines. Although lymphoid tissues of the female reproductive tract differ from that of the gut, many of the strategies and evolving principles may be directly applicable to the development of vaccines designed to prevent sexually transmitted diseases.

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Published In

Reprod Fertil Dev

DOI

ISSN

1031-3613

Publication Date

1994

Volume

6

Issue

3

Start / End Page

369 / 379

Location

Australia

Related Subject Headings

  • Th2 Cells
  • Tetanus Toxoid
  • Spleen
  • Peyer's Patches
  • Obstetrics & Reproductive Medicine
  • Mucous Membrane
  • Mice, Inbred C57BL
  • Mice, Inbred C3H
  • Mice
  • Immunoglobulin G
 

Citation

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McGhee, J. R., Xu-Amano, J., Miller, C. J., Jackson, R. J., Fujihashi, K., Staats, H. F., & Kiyono, H. (1994). The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract. Reprod Fertil Dev, 6(3), 369–379. https://doi.org/10.1071/rd9940369
McGhee, J. R., J. Xu-Amano, C. J. Miller, R. J. Jackson, K. Fujihashi, H. F. Staats, and H. Kiyono. “The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract.Reprod Fertil Dev 6, no. 3 (1994): 369–79. https://doi.org/10.1071/rd9940369.
McGhee JR, Xu-Amano J, Miller CJ, Jackson RJ, Fujihashi K, Staats HF, et al. The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract. Reprod Fertil Dev. 1994;6(3):369–79.
McGhee, J. R., et al. “The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract.Reprod Fertil Dev, vol. 6, no. 3, 1994, pp. 369–79. Pubmed, doi:10.1071/rd9940369.
McGhee JR, Xu-Amano J, Miller CJ, Jackson RJ, Fujihashi K, Staats HF, Kiyono H. The common mucosal immune system: from basic principles to enteric vaccines with relevance for the female reproductive tract. Reprod Fertil Dev. 1994;6(3):369–379.
Journal cover image

Published In

Reprod Fertil Dev

DOI

ISSN

1031-3613

Publication Date

1994

Volume

6

Issue

3

Start / End Page

369 / 379

Location

Australia

Related Subject Headings

  • Th2 Cells
  • Tetanus Toxoid
  • Spleen
  • Peyer's Patches
  • Obstetrics & Reproductive Medicine
  • Mucous Membrane
  • Mice, Inbred C57BL
  • Mice, Inbred C3H
  • Mice
  • Immunoglobulin G