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Carcinoma of the tonsillar region: a multivariate analysis of 243 patients treated with radical radiotherapy.

Publication ,  Journal Article
Lee, WR; Mendenhall, WM; Parsons, JT; Million, RR; Cassisi, NJ; Stringer, SP
Published in: Head Neck
1993

Between October 1964 and June 1990, 243 patients with squamous cell carcinoma of the tonsillar region were treated with continuous-course radical radiotherapy at the University of Florida. All patients had a minimum 2-year follow-up. Patients were staged according to the AJCC system; stage IV was stratified into two subsets: favorable, IVA (T1-T3 or N2A-N3A); and unfavorable, IVB (T4 or N3B). The initial and ultimate local control rates (including surgical salvage) according to T stage were as follows: T1, 87% and 100%, T2, 79% and 92%; T3, 71% and 76%; and T4, 44% and 48%. Multivariate analysis demonstrated that anterior extension of the primary tumor (p = .0001) and T stage (p = .014) were the most significant parameters affecting local control after radiotherapy. For T4 lesions, twice-daily irradiation significantly improved local control (p = .04). The 5-year absolute and cause-specific survival rates as a function of modified AJCC stage were as follows: I, 37% and 100%; II, 55% and 90%; III, 55% and 85%; IVA, 35% and 60%; and IVB, 23% and 38%. The probability of a severe complication was 3% for the entire group of patients.

Duke Scholars

Published In

Head Neck

DOI

ISSN

1043-3074

Publication Date

1993

Volume

15

Issue

4

Start / End Page

283 / 288

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tonsillar Neoplasms
  • Survival Rate
  • Salvage Therapy
  • Radium
  • Radiotherapy, High-Energy
  • Radiotherapy Dosage
  • Otorhinolaryngology
  • Osteoradionecrosis
  • Neoplasm Staging
 

Citation

APA
Chicago
ICMJE
MLA
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Lee, W. R., Mendenhall, W. M., Parsons, J. T., Million, R. R., Cassisi, N. J., & Stringer, S. P. (1993). Carcinoma of the tonsillar region: a multivariate analysis of 243 patients treated with radical radiotherapy. Head Neck, 15(4), 283–288. https://doi.org/10.1002/hed.2880150402
Lee, W. R., W. M. Mendenhall, J. T. Parsons, R. R. Million, N. J. Cassisi, and S. P. Stringer. “Carcinoma of the tonsillar region: a multivariate analysis of 243 patients treated with radical radiotherapy.Head Neck 15, no. 4 (1993): 283–88. https://doi.org/10.1002/hed.2880150402.
Lee WR, Mendenhall WM, Parsons JT, Million RR, Cassisi NJ, Stringer SP. Carcinoma of the tonsillar region: a multivariate analysis of 243 patients treated with radical radiotherapy. Head Neck. 1993;15(4):283–8.
Lee, W. R., et al. “Carcinoma of the tonsillar region: a multivariate analysis of 243 patients treated with radical radiotherapy.Head Neck, vol. 15, no. 4, 1993, pp. 283–88. Pubmed, doi:10.1002/hed.2880150402.
Lee WR, Mendenhall WM, Parsons JT, Million RR, Cassisi NJ, Stringer SP. Carcinoma of the tonsillar region: a multivariate analysis of 243 patients treated with radical radiotherapy. Head Neck. 1993;15(4):283–288.
Journal cover image

Published In

Head Neck

DOI

ISSN

1043-3074

Publication Date

1993

Volume

15

Issue

4

Start / End Page

283 / 288

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tonsillar Neoplasms
  • Survival Rate
  • Salvage Therapy
  • Radium
  • Radiotherapy, High-Energy
  • Radiotherapy Dosage
  • Otorhinolaryngology
  • Osteoradionecrosis
  • Neoplasm Staging