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Prophylaxis and treatment of acute graft-versus-host disease.

Publication ,  Journal Article
Chao, NJ; Chen, BJ
Published in: Semin Hematol
January 2006

Acute graft-versus-host disease (GVHD) remains a major obstacle to successful allogeneic hematopoietic stem cell transplantation (HSCT). The ability to prevent GVHD--the application of successful prophylaxis--is crucial as treatment when prophylaxis fails or remains suboptimal. A calcineurin inhibitor in combination with methotrexate is still the mainstream regimen for prophylaxis of GVHD. Despite a steady increase in the repertoire of available drugs, corticosteroids remain the first-line therapy for patients who fail prevention and develop GVHD. Pan T-cell depletion studies suggest that success in prophylaxis and treatment of GVHD will depend on whether GVHD can be prevented without losing anti-malignancy and anti-infectious effects. Better understanding of the allogeneic response that is responsible for GVHD will facilitate the development of such an approach.

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Published In

Semin Hematol

DOI

ISSN

0037-1963

Publication Date

January 2006

Volume

43

Issue

1

Start / End Page

32 / 41

Location

United States

Related Subject Headings

  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Graft vs Host Disease
  • Acute Disease
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

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Chao, N. J., & Chen, B. J. (2006). Prophylaxis and treatment of acute graft-versus-host disease. Semin Hematol, 43(1), 32–41. https://doi.org/10.1053/j.seminhematol.2005.09.007
Chao, Nelson J., and Benny J. Chen. “Prophylaxis and treatment of acute graft-versus-host disease.Semin Hematol 43, no. 1 (January 2006): 32–41. https://doi.org/10.1053/j.seminhematol.2005.09.007.
Chao NJ, Chen BJ. Prophylaxis and treatment of acute graft-versus-host disease. Semin Hematol. 2006 Jan;43(1):32–41.
Chao, Nelson J., and Benny J. Chen. “Prophylaxis and treatment of acute graft-versus-host disease.Semin Hematol, vol. 43, no. 1, Jan. 2006, pp. 32–41. Pubmed, doi:10.1053/j.seminhematol.2005.09.007.
Chao NJ, Chen BJ. Prophylaxis and treatment of acute graft-versus-host disease. Semin Hematol. 2006 Jan;43(1):32–41.
Journal cover image

Published In

Semin Hematol

DOI

ISSN

0037-1963

Publication Date

January 2006

Volume

43

Issue

1

Start / End Page

32 / 41

Location

United States

Related Subject Headings

  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Graft vs Host Disease
  • Acute Disease
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology