Prophylaxis and treatment of acute graft-versus-host disease.
Acute graft-versus-host disease (GVHD) remains a major obstacle to successful allogeneic hematopoietic stem cell transplantation (HSCT). The ability to prevent GVHD--the application of successful prophylaxis--is crucial as treatment when prophylaxis fails or remains suboptimal. A calcineurin inhibitor in combination with methotrexate is still the mainstream regimen for prophylaxis of GVHD. Despite a steady increase in the repertoire of available drugs, corticosteroids remain the first-line therapy for patients who fail prevention and develop GVHD. Pan T-cell depletion studies suggest that success in prophylaxis and treatment of GVHD will depend on whether GVHD can be prevented without losing anti-malignancy and anti-infectious effects. Better understanding of the allogeneic response that is responsible for GVHD will facilitate the development of such an approach.
Duke Scholars
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- Immunology
- Humans
- Hematopoietic Stem Cell Transplantation
- Graft vs Host Disease
- Acute Disease
- 3201 Cardiovascular medicine and haematology
- 1102 Cardiorespiratory Medicine and Haematology
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Immunology
- Humans
- Hematopoietic Stem Cell Transplantation
- Graft vs Host Disease
- Acute Disease
- 3201 Cardiovascular medicine and haematology
- 1102 Cardiorespiratory Medicine and Haematology