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Infection due to Actinobacillus actinomycetemcomitans: 15 cases and review.

Publication ,  Journal Article
Kaplan, AH; Weber, DJ; Oddone, EZ; Perfect, JR
Published in: Rev Infect Dis
1989

Actinobacillus actinomycetemcomitans is a small fastidious gram-negative coccobacillus that fails to grow on MacConkey's agar. Slow growth in broth may lead to delays in diagnosis. First described in 1912, A. actinomycetemcomitans has been recognized since 1962 as capable of causing serious infections in humans. Such infections include periodontal infection, soft tissue abscess (often in association with Actinomyces species), and systemic infection, most commonly endocarditis. Fifteen cases and a review of the English-language literature are presented to define the epidemiology and clinical features of infection due to A. actinomycetemcomitans. Therapy for infection due to A. actinomycetemcomitans has most commonly involved ampicillin or penicillin, often in conjunction with an aminoglycoside. However, resistance to penicillin or ampicillin is common. Antimicrobial agents with a high degree of in vitro activity included cefazolin, cefotaxime, cetriaxone, aminoglycosides, and chloramphenicol. Therapy should be guided by clinical response and in vitro susceptibility testing.

Duke Scholars

Published In

Rev Infect Dis

DOI

ISSN

0162-0886

Publication Date

1989

Volume

11

Issue

1

Start / End Page

46 / 63

Location

United States

Related Subject Headings

  • Middle Aged
  • Male
  • Humans
  • Female
  • Adult
  • Actinobacillus Infections
 

Citation

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Kaplan, A. H., Weber, D. J., Oddone, E. Z., & Perfect, J. R. (1989). Infection due to Actinobacillus actinomycetemcomitans: 15 cases and review. Rev Infect Dis, 11(1), 46–63. https://doi.org/10.1093/clinids/11.1.46
Kaplan, A. H., D. J. Weber, E. Z. Oddone, and J. R. Perfect. “Infection due to Actinobacillus actinomycetemcomitans: 15 cases and review.Rev Infect Dis 11, no. 1 (1989): 46–63. https://doi.org/10.1093/clinids/11.1.46.
Kaplan AH, Weber DJ, Oddone EZ, Perfect JR. Infection due to Actinobacillus actinomycetemcomitans: 15 cases and review. Rev Infect Dis. 1989;11(1):46–63.
Kaplan, A. H., et al. “Infection due to Actinobacillus actinomycetemcomitans: 15 cases and review.Rev Infect Dis, vol. 11, no. 1, 1989, pp. 46–63. Pubmed, doi:10.1093/clinids/11.1.46.
Kaplan AH, Weber DJ, Oddone EZ, Perfect JR. Infection due to Actinobacillus actinomycetemcomitans: 15 cases and review. Rev Infect Dis. 1989;11(1):46–63.

Published In

Rev Infect Dis

DOI

ISSN

0162-0886

Publication Date

1989

Volume

11

Issue

1

Start / End Page

46 / 63

Location

United States

Related Subject Headings

  • Middle Aged
  • Male
  • Humans
  • Female
  • Adult
  • Actinobacillus Infections