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Increased substance P receptor expression by blood vessels and lymphoid aggregates in Clostridium difficile-induced pseudomembranous colitis.

Publication ,  Journal Article
Mantyh, CR; Maggio, JE; Mantyh, PW; Vigna, SR; Pappas, TN
Published in: Dig Dis Sci
March 1996

Pseudomembranous colitis is most often caused by toxins secreted by Clostridium difficile following bowel flora overgrowth after antibiotic use. The secretory and inflammatory effects observed in C. difficile toxin A-induced enterocolitis in the rat ileum are inhibited by CP-96,345, a substance P (SP) receptor antagonist. To determine if SP plays a role in the pathogenesis of human pseudomembranous colitis, SP receptor distribution was examined in a toxin A-positive specimen of bowel. Quantitative receptor autoradiography was used to examine SP receptors in tissue from a patient who tested positive for C. Difficile toxin. SP receptors were massively increased in small blood vessels and lymphoid aggregates in the pseudomembranous colitis bowel in comparison to control specimens. The SP binding was saturable and exhibited similar affinities for SP and CP-96,345. SP may contribute to the inflammatory response in pseudomembranous colitis via a massive increase in SP receptor antagonists may offer a novel therapeutic intervention for pseudomembranous colitis.

Duke Scholars

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

March 1996

Volume

41

Issue

3

Start / End Page

614 / 620

Location

United States

Related Subject Headings

  • Receptors, Neurokinin-1
  • Lymphoid Tissue
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Enterocolitis, Pseudomembranous
  • Emergencies
  • Combined Modality Therapy
  • Colon
  • Blood Vessels
 

Citation

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Mantyh, C. R., Maggio, J. E., Mantyh, P. W., Vigna, S. R., & Pappas, T. N. (1996). Increased substance P receptor expression by blood vessels and lymphoid aggregates in Clostridium difficile-induced pseudomembranous colitis. Dig Dis Sci, 41(3), 614–620. https://doi.org/10.1007/BF02282350
Mantyh, C. R., J. E. Maggio, P. W. Mantyh, S. R. Vigna, and T. N. Pappas. “Increased substance P receptor expression by blood vessels and lymphoid aggregates in Clostridium difficile-induced pseudomembranous colitis.Dig Dis Sci 41, no. 3 (March 1996): 614–20. https://doi.org/10.1007/BF02282350.
Mantyh, C. R., et al. “Increased substance P receptor expression by blood vessels and lymphoid aggregates in Clostridium difficile-induced pseudomembranous colitis.Dig Dis Sci, vol. 41, no. 3, Mar. 1996, pp. 614–20. Pubmed, doi:10.1007/BF02282350.
Journal cover image

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

March 1996

Volume

41

Issue

3

Start / End Page

614 / 620

Location

United States

Related Subject Headings

  • Receptors, Neurokinin-1
  • Lymphoid Tissue
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Enterocolitis, Pseudomembranous
  • Emergencies
  • Combined Modality Therapy
  • Colon
  • Blood Vessels