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Receptors for sensory neuropeptides in human inflammatory diseases: implications for the effector role of sensory neurons.

Publication ,  Journal Article
Mantyh, PW; Catton, MD; Boehmer, CG; Welton, ML; Passaro, EP; Maggio, JE; Vigna, SR
Published in: Peptides
1989

Glutamate and several neuropeptides are synthesized and released by subpopulations of primary afferent neurons. These sensory neurons play a role in regulating the inflammatory and immune responses in peripheral tissues. Using quantitative receptor autoradiography we have explored what changes occur in the location and concentration of receptor binding sites for sensory neurotransmitters in the colon in two human inflammatory diseases, ulcerative colitis and Crohn's disease. The sensory neurotransmitter receptors examined included bombesin, calcitonin gene related peptide-alpha, cholecystokinin, galanin, glutamate, somatostatin, neurokinin A (substance K), substance P, and vasoactive intestinal polypeptide. Of the nine receptor binding sites examined only substance P binding sites associated with arterioles, venules and lymph nodules were dramatically up-regulated in the inflamed tissue. These data suggest that substance P is involved in regulating the inflammatory and immune responses in human inflammatory diseases and indicate a specificity of efferent action for each sensory neurotransmitter in peripheral tissues.

Duke Scholars

Published In

Peptides

DOI

ISSN

0196-9781

Publication Date

1989

Volume

10

Issue

3

Start / End Page

627 / 645

Location

United States

Related Subject Headings

  • Reference Values
  • Receptors, Neurotransmitter
  • Neuropeptides
  • Neurons, Afferent
  • Iodine Radioisotopes
  • Inflammation
  • Humans
  • Crohn Disease
  • Colon
  • Colitis, Ulcerative
 

Citation

APA
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ICMJE
MLA
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Mantyh, P. W., Catton, M. D., Boehmer, C. G., Welton, M. L., Passaro, E. P., Maggio, J. E., & Vigna, S. R. (1989). Receptors for sensory neuropeptides in human inflammatory diseases: implications for the effector role of sensory neurons. Peptides, 10(3), 627–645. https://doi.org/10.1016/0196-9781(89)90154-x
Mantyh, P. W., M. D. Catton, C. G. Boehmer, M. L. Welton, E. P. Passaro, J. E. Maggio, and S. R. Vigna. “Receptors for sensory neuropeptides in human inflammatory diseases: implications for the effector role of sensory neurons.Peptides 10, no. 3 (1989): 627–45. https://doi.org/10.1016/0196-9781(89)90154-x.
Mantyh PW, Catton MD, Boehmer CG, Welton ML, Passaro EP, Maggio JE, et al. Receptors for sensory neuropeptides in human inflammatory diseases: implications for the effector role of sensory neurons. Peptides. 1989;10(3):627–45.
Mantyh, P. W., et al. “Receptors for sensory neuropeptides in human inflammatory diseases: implications for the effector role of sensory neurons.Peptides, vol. 10, no. 3, 1989, pp. 627–45. Pubmed, doi:10.1016/0196-9781(89)90154-x.
Mantyh PW, Catton MD, Boehmer CG, Welton ML, Passaro EP, Maggio JE, Vigna SR. Receptors for sensory neuropeptides in human inflammatory diseases: implications for the effector role of sensory neurons. Peptides. 1989;10(3):627–645.
Journal cover image

Published In

Peptides

DOI

ISSN

0196-9781

Publication Date

1989

Volume

10

Issue

3

Start / End Page

627 / 645

Location

United States

Related Subject Headings

  • Reference Values
  • Receptors, Neurotransmitter
  • Neuropeptides
  • Neurons, Afferent
  • Iodine Radioisotopes
  • Inflammation
  • Humans
  • Crohn Disease
  • Colon
  • Colitis, Ulcerative