Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system.
Publication
, Journal Article
Markert, ML; Cresswell, P
Published in: Proc Natl Acad Sci U S A
October 1980
The B-cell alloantigens of an HLA-DR3-homozygous, MB2-homozygous, MT2-positive lymphoblastoid cell line were studied by two-dimensional gel electrophoresis. Analysis of gel patterns suggested assignment of the HLA-DR3 determinant to the larger (35,000-dalton) subunit (alpha) of the B-cell alloantigen. MB2 was found to be either a determinant on the small (27,000 dalton) subunit (beta) or a crossreactive determinant(s) on the HLA-DR3 alpha subunit and an additional alpha subunit. MT2 was found to be a determinant on Ia antigen-like molecules distinct from those carrying the MB and HLA-DR determinants. The results are consistent with the existence in the major histocompatibility complex of at least three loci encoding B-cell alloantigens.
Duke Scholars
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
October 1980
Volume
77
Issue
10
Start / End Page
6101 / 6104
Location
United States
Related Subject Headings
- Polymorphism, Genetic
- Major Histocompatibility Complex
- Macromolecular Substances
- Isoantigens
- Humans
- Histocompatibility Antigens Class II
- HLA Antigens
- Epitopes
- B-Lymphocytes
Citation
APA
Chicago
ICMJE
MLA
NLM
Markert, M. L., & Cresswell, P. (1980). Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system. Proc Natl Acad Sci U S A, 77(10), 6101–6104. https://doi.org/10.1073/pnas.77.10.6101
Markert, M. L., and P. Cresswell. “Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system.” Proc Natl Acad Sci U S A 77, no. 10 (October 1980): 6101–4. https://doi.org/10.1073/pnas.77.10.6101.
Markert ML, Cresswell P. Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system. Proc Natl Acad Sci U S A. 1980 Oct;77(10):6101–4.
Markert, M. L., and P. Cresswell. “Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system.” Proc Natl Acad Sci U S A, vol. 77, no. 10, Oct. 1980, pp. 6101–04. Pubmed, doi:10.1073/pnas.77.10.6101.
Markert ML, Cresswell P. Polymorphism of human B-cell alloantigens: evidence for three loci within the HLA system. Proc Natl Acad Sci U S A. 1980 Oct;77(10):6101–6104.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
October 1980
Volume
77
Issue
10
Start / End Page
6101 / 6104
Location
United States
Related Subject Headings
- Polymorphism, Genetic
- Major Histocompatibility Complex
- Macromolecular Substances
- Isoantigens
- Humans
- Histocompatibility Antigens Class II
- HLA Antigens
- Epitopes
- B-Lymphocytes