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A cell-based model of coagulation and the role of factor VIIa.

Publication ,  Journal Article
Hoffman, M
Published in: Blood Rev
September 2003

Our cell-based model of haemostasis replaces the traditional 'cascade' hypothesis, and proposes that coagulation takes place on different cell surfaces in three overlapping steps: initiation, amplification, and propagation. In highlighting the importance of cellular control during coagulation, the cell-based model allows a more thorough understanding of how haemostasis works in vivo, and sheds light on the pathophysiological mechanisms behind certain coagulation disorders. For instance, this model proposes that haemophilia involves a failure of platelet-surface FXa generation, leading to a lack of platelet-surface thrombin production. Our data suggest that high-dose FVIIa is able to bind weakly to activated platelets, independently of tissue factor, in order to generate sufficient amounts of FXa to support a burst bf thrombin generation in the absence of FIXa/FVIIIa. The considerable success of high-dose recombinant FVIIa (rFVIIa; NovoSeven, Novo Nordisk, Copenhagen, Denmark) as a therapy for patients with haemophilia and inhibitors has led to its use in a growing number of alternative indications. We believe that even in the presence of the FIXa/FVIIIa complex, rFVIIa may be able to enhance both FXa and FIXa levels on the surface of activated platelets, thus increasing the production of thrombin.

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Published In

Blood Rev

DOI

ISSN

0268-960X

Publication Date

September 2003

Volume

17 Suppl 1

Start / End Page

S1 / S5

Location

England

Related Subject Headings

  • Monocytes
  • Immunology
  • Humans
  • Hemostasis
  • Hemophilia A
  • Factor VIIa
  • Blood Platelets
  • Blood Coagulation
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
 

Citation

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ICMJE
MLA
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Hoffman, M. (2003). A cell-based model of coagulation and the role of factor VIIa. Blood Rev, 17 Suppl 1, S1–S5. https://doi.org/10.1016/s0268-960x(03)90000-2
Hoffman, Maureane. “A cell-based model of coagulation and the role of factor VIIa.Blood Rev 17 Suppl 1 (September 2003): S1–5. https://doi.org/10.1016/s0268-960x(03)90000-2.
Hoffman M. A cell-based model of coagulation and the role of factor VIIa. Blood Rev. 2003 Sep;17 Suppl 1:S1–5.
Hoffman, Maureane. “A cell-based model of coagulation and the role of factor VIIa.Blood Rev, vol. 17 Suppl 1, Sept. 2003, pp. S1–5. Pubmed, doi:10.1016/s0268-960x(03)90000-2.
Hoffman M. A cell-based model of coagulation and the role of factor VIIa. Blood Rev. 2003 Sep;17 Suppl 1:S1–S5.
Journal cover image

Published In

Blood Rev

DOI

ISSN

0268-960X

Publication Date

September 2003

Volume

17 Suppl 1

Start / End Page

S1 / S5

Location

England

Related Subject Headings

  • Monocytes
  • Immunology
  • Humans
  • Hemostasis
  • Hemophilia A
  • Factor VIIa
  • Blood Platelets
  • Blood Coagulation
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences