Venous thrombosis in a family with defective release of vascular plasminogen activator and elevated plasma factor VIII/von Willebrand's factor.
Publication
, Journal Article
Stead, NW; Bauer, KA; Kinney, TR; Lewis, JG; Campbell, EE; Shifman, MA; Rosenberg, RD; Pizzo, SV
Published in: Am J Med
January 1983
A family is described in which venous thrombosis developed in five members as early as 14 years of age. Routine coagulation studies, plasma antithrombin III, factor V, plasminogen, beta-thromboglobulin, fibrinopeptide A, prothrombin fragment F1+2, and thrombin-antithrombin III complex were all within normal limits. However, defective release of vascular plasminogen activator was observed on several occasions in all five subjects as compared with a control population of 125 persons (0.04 Committee on Thrombolytic Agents [CTA] units/ml plasma as compared with 0.21 CTS units/ml). In addition, levels of factor VII/von Willebrand's factor were significantly elevated above the normal range in this pedigree.
Duke Scholars
Published In
Am J Med
DOI
ISSN
0002-9343
Publication Date
January 1983
Volume
74
Issue
1
Start / End Page
33 / 39
Location
United States
Related Subject Headings
- von Willebrand Factor
- Thrombophlebitis
- Thrombin
- Platelet Aggregation
- Plasminogen Activators
- Plasminogen
- Pedigree
- Male
- Humans
- General & Internal Medicine
Citation
APA
Chicago
ICMJE
MLA
NLM
Stead, N. W., Bauer, K. A., Kinney, T. R., Lewis, J. G., Campbell, E. E., Shifman, M. A., … Pizzo, S. V. (1983). Venous thrombosis in a family with defective release of vascular plasminogen activator and elevated plasma factor VIII/von Willebrand's factor. Am J Med, 74(1), 33–39. https://doi.org/10.1016/0002-9343(83)91115-4
Stead, N. W., K. A. Bauer, T. R. Kinney, J. G. Lewis, E. E. Campbell, M. A. Shifman, R. D. Rosenberg, and S. V. Pizzo. “Venous thrombosis in a family with defective release of vascular plasminogen activator and elevated plasma factor VIII/von Willebrand's factor.” Am J Med 74, no. 1 (January 1983): 33–39. https://doi.org/10.1016/0002-9343(83)91115-4.
Stead NW, Bauer KA, Kinney TR, Lewis JG, Campbell EE, Shifman MA, et al. Venous thrombosis in a family with defective release of vascular plasminogen activator and elevated plasma factor VIII/von Willebrand's factor. Am J Med. 1983 Jan;74(1):33–9.
Stead, N. W., et al. “Venous thrombosis in a family with defective release of vascular plasminogen activator and elevated plasma factor VIII/von Willebrand's factor.” Am J Med, vol. 74, no. 1, Jan. 1983, pp. 33–39. Pubmed, doi:10.1016/0002-9343(83)91115-4.
Stead NW, Bauer KA, Kinney TR, Lewis JG, Campbell EE, Shifman MA, Rosenberg RD, Pizzo SV. Venous thrombosis in a family with defective release of vascular plasminogen activator and elevated plasma factor VIII/von Willebrand's factor. Am J Med. 1983 Jan;74(1):33–39.
Published In
Am J Med
DOI
ISSN
0002-9343
Publication Date
January 1983
Volume
74
Issue
1
Start / End Page
33 / 39
Location
United States
Related Subject Headings
- von Willebrand Factor
- Thrombophlebitis
- Thrombin
- Platelet Aggregation
- Plasminogen Activators
- Plasminogen
- Pedigree
- Male
- Humans
- General & Internal Medicine