Skip to main content
construction release_alert
The Scholars Team is working with OIT to resolve some issues with the Scholars search index
cancel
Journal cover image

Vascular plasminogen activator levels and thromboembolic disease in patients with gynecologic malignancies.

Publication ,  Journal Article
Gore, M; Miller, KE; Soong, SJ; Clarke-Pearson, DL; Pizzo, SV
Published in: Am J Obstet Gynecol
August 15, 1984

Vascular plasminogen activator levels were measured preoperatively in 66 women with gynecologic malignancies. These levels were compared to levels in a matched control group of 84 women and to the incidence of postoperative venous thromboembolic disease in the patient group. Significantly lower levels of plasminogen activator were measured in patients who developed thrombotic complications (p = 0.0014). When results were stratified according to tumor location, patients with ovarian carcinoma had significantly higher activator levels than those found in control subjects (p = 0.0072), and significantly lower levels were associated with endometrial malignancy (p = 0.0140). Measurement of releasable plasminogen activator before operation may be an effective, noninvasive means of identifying patients potentially at risk for venous thromboembolic disease. Postoperative measurement of plasminogen activator may eventually find a role in monitoring tumor therapy and recurrence.

Duke Scholars

Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

August 15, 1984

Volume

149

Issue

8

Start / End Page

830 / 834

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Thromboembolism
  • Postoperative Complications
  • Plethysmography, Impedance
  • Plasminogen Activators
  • Ovarian Neoplasms
  • Obstetrics & Reproductive Medicine
  • Iodine Radioisotopes
  • Humans
  • Genital Neoplasms, Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gore, M., Miller, K. E., Soong, S. J., Clarke-Pearson, D. L., & Pizzo, S. V. (1984). Vascular plasminogen activator levels and thromboembolic disease in patients with gynecologic malignancies. Am J Obstet Gynecol, 149(8), 830–834. https://doi.org/10.1016/0002-9378(84)90599-4
Gore, M., K. E. Miller, S. J. Soong, D. L. Clarke-Pearson, and S. V. Pizzo. “Vascular plasminogen activator levels and thromboembolic disease in patients with gynecologic malignancies.Am J Obstet Gynecol 149, no. 8 (August 15, 1984): 830–34. https://doi.org/10.1016/0002-9378(84)90599-4.
Gore M, Miller KE, Soong SJ, Clarke-Pearson DL, Pizzo SV. Vascular plasminogen activator levels and thromboembolic disease in patients with gynecologic malignancies. Am J Obstet Gynecol. 1984 Aug 15;149(8):830–4.
Gore, M., et al. “Vascular plasminogen activator levels and thromboembolic disease in patients with gynecologic malignancies.Am J Obstet Gynecol, vol. 149, no. 8, Aug. 1984, pp. 830–34. Pubmed, doi:10.1016/0002-9378(84)90599-4.
Gore M, Miller KE, Soong SJ, Clarke-Pearson DL, Pizzo SV. Vascular plasminogen activator levels and thromboembolic disease in patients with gynecologic malignancies. Am J Obstet Gynecol. 1984 Aug 15;149(8):830–834.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

August 15, 1984

Volume

149

Issue

8

Start / End Page

830 / 834

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Thromboembolism
  • Postoperative Complications
  • Plethysmography, Impedance
  • Plasminogen Activators
  • Ovarian Neoplasms
  • Obstetrics & Reproductive Medicine
  • Iodine Radioisotopes
  • Humans
  • Genital Neoplasms, Female