Model of alpha 2-macroglobulin structure and function.
Publication
, Journal Article
Feldman, SR; Gonias, SL; Pizzo, SV
Published in: Proc Natl Acad Sci U S A
September 1985
A model of alpha 2-macroglobulin is presented that is compatible with previous structural, functional, and phylogenetic studies of the protein. The model of the molecule resembles a hollow cylinder and is comprised of two identical functional halves with three C2 axes of symmetry and no mirror planes. The "trap mechanism" of this proteinase inhibitor is effected by slight movement of two trap arms per "half-molecule." Evidence for this model is obtained from the study of the structure and proteinase binding of the molecule. By using this model, predictions are made concerning proteinase binding ratios, receptor recognition, and "slow-to-fast" conformational change of the molecule.
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Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
September 1985
Volume
82
Issue
17
Start / End Page
5700 / 5704
Location
United States
Related Subject Headings
- alpha-Macroglobulins
- Structure-Activity Relationship
- Protein Conformation
- Protein Binding
- Protease Inhibitors
- Models, Structural
- Microscopy, Electron
- Macromolecular Substances
- Kinetics
- Humans
Citation
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MLA
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Feldman, S. R., Gonias, S. L., & Pizzo, S. V. (1985). Model of alpha 2-macroglobulin structure and function. Proc Natl Acad Sci U S A, 82(17), 5700–5704. https://doi.org/10.1073/pnas.82.17.5700
Feldman, S. R., S. L. Gonias, and S. V. Pizzo. “Model of alpha 2-macroglobulin structure and function.” Proc Natl Acad Sci U S A 82, no. 17 (September 1985): 5700–5704. https://doi.org/10.1073/pnas.82.17.5700.
Feldman SR, Gonias SL, Pizzo SV. Model of alpha 2-macroglobulin structure and function. Proc Natl Acad Sci U S A. 1985 Sep;82(17):5700–4.
Feldman, S. R., et al. “Model of alpha 2-macroglobulin structure and function.” Proc Natl Acad Sci U S A, vol. 82, no. 17, Sept. 1985, pp. 5700–04. Pubmed, doi:10.1073/pnas.82.17.5700.
Feldman SR, Gonias SL, Pizzo SV. Model of alpha 2-macroglobulin structure and function. Proc Natl Acad Sci U S A. 1985 Sep;82(17):5700–5704.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
September 1985
Volume
82
Issue
17
Start / End Page
5700 / 5704
Location
United States
Related Subject Headings
- alpha-Macroglobulins
- Structure-Activity Relationship
- Protein Conformation
- Protein Binding
- Protease Inhibitors
- Models, Structural
- Microscopy, Electron
- Macromolecular Substances
- Kinetics
- Humans