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Receptors for maleylated proteins regulate secretion of neutral proteases by murine macrophages.

Publication ,  Journal Article
Johnson, WJ; Pizzo, SV; Imber, MJ; Adams, DO
Published in: Science
November 5, 1982

Receptors for maleylated or acetylated proteins as well as for alpha-2-macroglobulin-protease complexes on macrophages serve as scavengers by mediating the uptake of macromolecules from the extracellular compartment. Described in this report is a novel function of these receptors on macrophages: regulation of neutral protease secretion. The binding of maleylated bovine serum albumin to macrophages triggered secretion of three neutral proteases: neutral caseinases, plasminogen activator, and cytolytic proteinase. Release of acid phosphatase, however, was not induced. An important biological consequence of protease secretion by macrophages, tumor-cytolysis, was also triggered by engagement of the receptor for maleylated bovine serum albumin. By contrast, the binding of alpha-2-macroglobulin-protease complexes to the macrophages suppressed secretion of all three proteases. Thus two receptors heretofore believed to serve principally as scavengers also regulate secretory functions of macrophages.

Duke Scholars

Published In

Science

DOI

ISSN

0036-8075

Publication Date

November 5, 1982

Volume

218

Issue

4572

Start / End Page

574 / 576

Location

United States

Related Subject Headings

  • Receptors, Cell Surface
  • Plasminogen Activators
  • Peptide Hydrolases
  • Mice
  • Metalloendopeptidases
  • Macrophages
  • Glycoproteins
  • General Science & Technology
  • Cells, Cultured
  • Animals
 

Citation

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Johnson, W. J., Pizzo, S. V., Imber, M. J., & Adams, D. O. (1982). Receptors for maleylated proteins regulate secretion of neutral proteases by murine macrophages. Science, 218(4572), 574–576. https://doi.org/10.1126/science.6289443
Johnson, W. J., S. V. Pizzo, M. J. Imber, and D. O. Adams. “Receptors for maleylated proteins regulate secretion of neutral proteases by murine macrophages.Science 218, no. 4572 (November 5, 1982): 574–76. https://doi.org/10.1126/science.6289443.
Johnson WJ, Pizzo SV, Imber MJ, Adams DO. Receptors for maleylated proteins regulate secretion of neutral proteases by murine macrophages. Science. 1982 Nov 5;218(4572):574–6.
Johnson, W. J., et al. “Receptors for maleylated proteins regulate secretion of neutral proteases by murine macrophages.Science, vol. 218, no. 4572, Nov. 1982, pp. 574–76. Pubmed, doi:10.1126/science.6289443.
Johnson WJ, Pizzo SV, Imber MJ, Adams DO. Receptors for maleylated proteins regulate secretion of neutral proteases by murine macrophages. Science. 1982 Nov 5;218(4572):574–576.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

November 5, 1982

Volume

218

Issue

4572

Start / End Page

574 / 576

Location

United States

Related Subject Headings

  • Receptors, Cell Surface
  • Plasminogen Activators
  • Peptide Hydrolases
  • Mice
  • Metalloendopeptidases
  • Macrophages
  • Glycoproteins
  • General Science & Technology
  • Cells, Cultured
  • Animals