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Antiepileptic effects of GABAb receptor activation in area CA3 of rat hippocampus.

Publication ,  Journal Article
Morrisett, RA; Lewis, DV; Swartzwelder, HS; Wilson, WA
Published in: Brain Res
January 15, 1993

The role of GABAb receptor activation in the expression of both interictal and ictal phenomena was investigated in slices of area CA3 of the rat hippocampal formation. Interictal-like bursts occurred following application of high frequency trains to the Schaffer collaterals. When two bursts were triggered using paired stimuli, profound depression of the second burst was seen 150-600 ms following the first burst. GABAb receptor antagonists potently reversed the paired pulse depression of the interictal-like bursts. Reversal of the paired depression was also accomplished by increasing the extracellular concentration of K+ by 2-3 mM. Additional experiments were performed in area CA3 to determine the role of GABAb receptor activation on the expression of ictal phenomena. Electrographic seizures (EGSs) were induced by application of high frequency trains. 2-Hydroxy-saclofen (200 microM) significantly decreased the duration of trains required to elicit EGSs. Taken together, these data suggest that GABAb receptor activation has potent inhibitory effects on both ictal and interictal-like events.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

January 15, 1993

Volume

600

Issue

2

Start / End Page

235 / 242

Location

Netherlands

Related Subject Headings

  • Receptors, GABA-A
  • Rats, Sprague-Dawley
  • Rats
  • Pyramidal Tracts
  • Potassium Channels
  • Potassium
  • Neurology & Neurosurgery
  • Male
  • Kindling, Neurologic
  • In Vitro Techniques
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Morrisett, R. A., Lewis, D. V., Swartzwelder, H. S., & Wilson, W. A. (1993). Antiepileptic effects of GABAb receptor activation in area CA3 of rat hippocampus. Brain Res, 600(2), 235–242. https://doi.org/10.1016/0006-8993(93)91378-6
Morrisett, R. A., D. V. Lewis, H. S. Swartzwelder, and W. A. Wilson. “Antiepileptic effects of GABAb receptor activation in area CA3 of rat hippocampus.Brain Res 600, no. 2 (January 15, 1993): 235–42. https://doi.org/10.1016/0006-8993(93)91378-6.
Morrisett RA, Lewis DV, Swartzwelder HS, Wilson WA. Antiepileptic effects of GABAb receptor activation in area CA3 of rat hippocampus. Brain Res. 1993 Jan 15;600(2):235–42.
Morrisett, R. A., et al. “Antiepileptic effects of GABAb receptor activation in area CA3 of rat hippocampus.Brain Res, vol. 600, no. 2, Jan. 1993, pp. 235–42. Pubmed, doi:10.1016/0006-8993(93)91378-6.
Morrisett RA, Lewis DV, Swartzwelder HS, Wilson WA. Antiepileptic effects of GABAb receptor activation in area CA3 of rat hippocampus. Brain Res. 1993 Jan 15;600(2):235–242.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

January 15, 1993

Volume

600

Issue

2

Start / End Page

235 / 242

Location

Netherlands

Related Subject Headings

  • Receptors, GABA-A
  • Rats, Sprague-Dawley
  • Rats
  • Pyramidal Tracts
  • Potassium Channels
  • Potassium
  • Neurology & Neurosurgery
  • Male
  • Kindling, Neurologic
  • In Vitro Techniques