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Phaclofen antagonizes post-tetanic disinhibition in the rat dentate gyrus.

Publication ,  Journal Article
Mott, DD; Bragdon, AC; Lewis, DV
Published in: Neurosci Lett
March 2, 1990

Tetanic mossy fiber stimulation transiently reduced recurrent inhibition in the rat dentate gyrus. The post-tetanic depression of inhibition was maximal 200 ms after the tetanus and typically lasted for about 2 s. Phaclofen, a selective gamma-aminobutyric acid-B (GABAB) receptor antagonist, significantly increased the post-tetanic level of inhibition. These results suggest that GABAB receptor activation is important for the development of post tetanic disinhibition. We suggest that GABA released during repetitive firing acts on GABAB receptors on inhibitory interneurons to suppress recurrent inhibition.

Duke Scholars

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

March 2, 1990

Volume

110

Issue

1-2

Start / End Page

131 / 136

Location

Ireland

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Neural Inhibition
  • Male
  • In Vitro Techniques
  • Hippocampus
  • Electric Stimulation
  • Baclofen
  • Animals
  • 5202 Biological psychology
 

Citation

APA
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ICMJE
MLA
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Mott, D. D., Bragdon, A. C., & Lewis, D. V. (1990). Phaclofen antagonizes post-tetanic disinhibition in the rat dentate gyrus. Neurosci Lett, 110(1–2), 131–136. https://doi.org/10.1016/0304-3940(90)90800-o
Mott, D. D., A. C. Bragdon, and D. V. Lewis. “Phaclofen antagonizes post-tetanic disinhibition in the rat dentate gyrus.Neurosci Lett 110, no. 1–2 (March 2, 1990): 131–36. https://doi.org/10.1016/0304-3940(90)90800-o.
Mott DD, Bragdon AC, Lewis DV. Phaclofen antagonizes post-tetanic disinhibition in the rat dentate gyrus. Neurosci Lett. 1990 Mar 2;110(1–2):131–6.
Mott, D. D., et al. “Phaclofen antagonizes post-tetanic disinhibition in the rat dentate gyrus.Neurosci Lett, vol. 110, no. 1–2, Mar. 1990, pp. 131–36. Pubmed, doi:10.1016/0304-3940(90)90800-o.
Mott DD, Bragdon AC, Lewis DV. Phaclofen antagonizes post-tetanic disinhibition in the rat dentate gyrus. Neurosci Lett. 1990 Mar 2;110(1–2):131–136.
Journal cover image

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

March 2, 1990

Volume

110

Issue

1-2

Start / End Page

131 / 136

Location

Ireland

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Neural Inhibition
  • Male
  • In Vitro Techniques
  • Hippocampus
  • Electric Stimulation
  • Baclofen
  • Animals
  • 5202 Biological psychology