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Diphenylhydantoin reduces the outward current of the action potential in Aplysia.

Publication ,  Journal Article
Lewis, DV
Published in: Brain Res
February 23, 1981

Diphenylhydantoin (DPH) has been shown to prolong the repolarization phase of action potentials in Aplysia and to reduce the spike after hyperpolarization. We voltage-clamped somata of Aplysia giant neurons and measured the action potential currents to determine what alterations might be responsible for the prolonged repolarization and reduced undershoot. DPH did not affect the peak inward current; however, it did reversibly reduce the outward current at concentrations of 38 microM or greater. The data indicate that DPH reduced the voltage sensitive potassium conductance rather than the 'A' current or the calcium activated potassium conductance. These changes in outward current would explain the prolonged action potentials and reduced afterhypolarization seen with DPH in Aplysia.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

February 23, 1981

Volume

207

Issue

1

Start / End Page

234 / 238

Location

Netherlands

Related Subject Headings

  • Synaptic Transmission
  • Potassium
  • Phenytoin
  • Neurons
  • Neurology & Neurosurgery
  • Ion Channels
  • Ganglia
  • Evoked Potentials
  • Calcium
  • Aplysia
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lewis, D. V. (1981). Diphenylhydantoin reduces the outward current of the action potential in Aplysia. Brain Res, 207(1), 234–238. https://doi.org/10.1016/0006-8993(81)90700-9
Lewis, D. V. “Diphenylhydantoin reduces the outward current of the action potential in Aplysia.Brain Res 207, no. 1 (February 23, 1981): 234–38. https://doi.org/10.1016/0006-8993(81)90700-9.
Lewis, D. V. “Diphenylhydantoin reduces the outward current of the action potential in Aplysia.Brain Res, vol. 207, no. 1, Feb. 1981, pp. 234–38. Pubmed, doi:10.1016/0006-8993(81)90700-9.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

February 23, 1981

Volume

207

Issue

1

Start / End Page

234 / 238

Location

Netherlands

Related Subject Headings

  • Synaptic Transmission
  • Potassium
  • Phenytoin
  • Neurons
  • Neurology & Neurosurgery
  • Ion Channels
  • Ganglia
  • Evoked Potentials
  • Calcium
  • Aplysia