Baclofen facilitates the development of long-term potentiation in the rat dentate gyrus.
Publication
, Journal Article
Mott, DD; Lewis, DV; Ferrari, CM; Wilson, WA; Swartzwelder, HS
Published in: Neurosci Lett
May 31, 1990
The effect of baclofen on the development of long-term potentiation (LTP) in the dentate gyrus was examined. Stimulus trains applied to the perforant path in the presence of baclofen produced significantly more potentiation of the perforant path-evoked response than did similar stimulation in control medium. In addition, baclofen enabled stimulus trains, ordinarily subthreshold for LTP induction, to produce LTP. These results demonstrate that GABAB receptor activation by baclofen makes repetitive stimulation more effective at producing LTP.
Duke Scholars
Published In
Neurosci Lett
DOI
ISSN
0304-3940
Publication Date
May 31, 1990
Volume
113
Issue
2
Start / End Page
222 / 226
Location
Ireland
Related Subject Headings
- Rats, Inbred Strains
- Rats
- Neuronal Plasticity
- Male
- In Vitro Techniques
- Hippocampus
- Electric Stimulation
- Baclofen
- Animals
- Action Potentials
Citation
APA
Chicago
ICMJE
MLA
NLM
Mott, D. D., Lewis, D. V., Ferrari, C. M., Wilson, W. A., & Swartzwelder, H. S. (1990). Baclofen facilitates the development of long-term potentiation in the rat dentate gyrus. Neurosci Lett, 113(2), 222–226. https://doi.org/10.1016/0304-3940(90)90307-u
Mott, D. D., D. V. Lewis, C. M. Ferrari, W. A. Wilson, and H. S. Swartzwelder. “Baclofen facilitates the development of long-term potentiation in the rat dentate gyrus.” Neurosci Lett 113, no. 2 (May 31, 1990): 222–26. https://doi.org/10.1016/0304-3940(90)90307-u.
Mott DD, Lewis DV, Ferrari CM, Wilson WA, Swartzwelder HS. Baclofen facilitates the development of long-term potentiation in the rat dentate gyrus. Neurosci Lett. 1990 May 31;113(2):222–6.
Mott, D. D., et al. “Baclofen facilitates the development of long-term potentiation in the rat dentate gyrus.” Neurosci Lett, vol. 113, no. 2, May 1990, pp. 222–26. Pubmed, doi:10.1016/0304-3940(90)90307-u.
Mott DD, Lewis DV, Ferrari CM, Wilson WA, Swartzwelder HS. Baclofen facilitates the development of long-term potentiation in the rat dentate gyrus. Neurosci Lett. 1990 May 31;113(2):222–226.
Published In
Neurosci Lett
DOI
ISSN
0304-3940
Publication Date
May 31, 1990
Volume
113
Issue
2
Start / End Page
222 / 226
Location
Ireland
Related Subject Headings
- Rats, Inbred Strains
- Rats
- Neuronal Plasticity
- Male
- In Vitro Techniques
- Hippocampus
- Electric Stimulation
- Baclofen
- Animals
- Action Potentials