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Potassium clearance and reactive gliosis in the alumina gel lesion.

Publication ,  Journal Article
Lewis, DV; Mutsuga, N; Schuette, WH; Van Buren, J
Published in: Epilepsia
December 1977

Potassium accumulation or impaired potassium clearance has been hypothesized to contribute to epileptogenesis in gliotic epileptogenic foci. To test this hypothesis, potassium clearance rates following direct cortical stimulation were measured in the cortex of monkeys rendered epileptic by the injection of alumina gel into the motor area. Reactive gliosis at the sites in which potassium clearance was measured was then quantitated histologically and compared with potassium clearance rates. Dense gliosis was associated with slowed potassium clearance, although the base-line potassium level appeared no different in actively epileptogenic areas or gliotic areas compared with normal areas. Possible mechanisms and significance of slowed potassium clearance in the alumina focus are discussed.

Duke Scholars

Published In

Epilepsia

DOI

ISSN

0013-9580

Publication Date

December 1977

Volume

18

Issue

4

Start / End Page

499 / 506

Location

United States

Related Subject Headings

  • Syndrome
  • Seizures
  • Potassium
  • Neurology & Neurosurgery
  • Macaca mulatta
  • Haplorhini
  • Gliosis
  • Electroencephalography
  • Animals
  • Aluminum Oxide
 

Citation

APA
Chicago
ICMJE
MLA
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Lewis, D. V., Mutsuga, N., Schuette, W. H., & Van Buren, J. (1977). Potassium clearance and reactive gliosis in the alumina gel lesion. Epilepsia, 18(4), 499–506. https://doi.org/10.1111/j.1528-1157.1977.tb04997.x
Lewis, D. V., N. Mutsuga, W. H. Schuette, and J. Van Buren. “Potassium clearance and reactive gliosis in the alumina gel lesion.Epilepsia 18, no. 4 (December 1977): 499–506. https://doi.org/10.1111/j.1528-1157.1977.tb04997.x.
Lewis DV, Mutsuga N, Schuette WH, Van Buren J. Potassium clearance and reactive gliosis in the alumina gel lesion. Epilepsia. 1977 Dec;18(4):499–506.
Lewis, D. V., et al. “Potassium clearance and reactive gliosis in the alumina gel lesion.Epilepsia, vol. 18, no. 4, Dec. 1977, pp. 499–506. Pubmed, doi:10.1111/j.1528-1157.1977.tb04997.x.
Lewis DV, Mutsuga N, Schuette WH, Van Buren J. Potassium clearance and reactive gliosis in the alumina gel lesion. Epilepsia. 1977 Dec;18(4):499–506.
Journal cover image

Published In

Epilepsia

DOI

ISSN

0013-9580

Publication Date

December 1977

Volume

18

Issue

4

Start / End Page

499 / 506

Location

United States

Related Subject Headings

  • Syndrome
  • Seizures
  • Potassium
  • Neurology & Neurosurgery
  • Macaca mulatta
  • Haplorhini
  • Gliosis
  • Electroencephalography
  • Animals
  • Aluminum Oxide