Human G(alpha q): cDNA and tissue distribution.

G(alpha q), a member of the Gq family of heterotrimeric G proteins, transduces signals from several G protein-coupled receptors that stimulate membrane phosphoinositide hydrolysis. In order to further define the role of G(alpha q) in the function of G protein-coupled receptors, we have cloned the cDNA encoding human G(alpha q) from a prostate cDNA library. Human G(alpha q) exhibits high homology with its mouse homolog - 94% similarity at the nucleotide level, and 99% similarity at the amino acid level. Northern hybridization data indicate high expression of G(alpha q) mRNA in organs of the human reproductive system including ovary, prostate, and testis.

Duke Scholars

Author Madan Mohan Kwatra Anesthesiology