Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Chimeric anti-tenascin antibody 81C6: increased tumor localization compared with its murine parent.

Publication ,  Journal Article
Zalutsky, MR; Archer, GE; Garg, PK; Batra, SK; Bigner, DD
Published in: Nucl Med Biol
May 1996

When labeled using the Iodogen method, a chimeric antibody composed of the human IgG2 constant region and the variable regions of murine anti-tenascin 81C6 exhibited superior uptake in human glioma xenografts compared with its murine parent. In the current study, three paired-label experiments were performed in athymic mice with subcutaneous D-54 MG human glioma xenografts to evaluate further the properties of radioiodinated chimeric 81C6. These studies demonstrated that (a) the enhanced tumor uptake of chimeric 81C6 is specific; (b) when labeling was performed using N-succinimidyl 3-iodobenzoate, chimeric 81C6 again showed preferential accumulation in tumor compared with murine 81C6; and (c) the tumor uptake advantage observed previously with murine 81C6 for N-succinimidyl 3-iodobenzoate compared with Iodogen labeling did not occur with chimeric 81C6.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nucl Med Biol

DOI

ISSN

0969-8051

Publication Date

May 1996

Volume

23

Issue

4

Start / End Page

449 / 458

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Tissue Distribution
  • Tenascin
  • Recombinant Fusion Proteins
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice
  • Isotope Labeling
  • Iodine Radioisotopes
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zalutsky, M. R., Archer, G. E., Garg, P. K., Batra, S. K., & Bigner, D. D. (1996). Chimeric anti-tenascin antibody 81C6: increased tumor localization compared with its murine parent. Nucl Med Biol, 23(4), 449–458. https://doi.org/10.1016/0969-8051(96)00021-2
Zalutsky, M. R., G. E. Archer, P. K. Garg, S. K. Batra, and D. D. Bigner. “Chimeric anti-tenascin antibody 81C6: increased tumor localization compared with its murine parent.Nucl Med Biol 23, no. 4 (May 1996): 449–58. https://doi.org/10.1016/0969-8051(96)00021-2.
Zalutsky MR, Archer GE, Garg PK, Batra SK, Bigner DD. Chimeric anti-tenascin antibody 81C6: increased tumor localization compared with its murine parent. Nucl Med Biol. 1996 May;23(4):449–58.
Zalutsky, M. R., et al. “Chimeric anti-tenascin antibody 81C6: increased tumor localization compared with its murine parent.Nucl Med Biol, vol. 23, no. 4, May 1996, pp. 449–58. Pubmed, doi:10.1016/0969-8051(96)00021-2.
Zalutsky MR, Archer GE, Garg PK, Batra SK, Bigner DD. Chimeric anti-tenascin antibody 81C6: increased tumor localization compared with its murine parent. Nucl Med Biol. 1996 May;23(4):449–458.
Journal cover image

Published In

Nucl Med Biol

DOI

ISSN

0969-8051

Publication Date

May 1996

Volume

23

Issue

4

Start / End Page

449 / 458

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Tissue Distribution
  • Tenascin
  • Recombinant Fusion Proteins
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice
  • Isotope Labeling
  • Iodine Radioisotopes