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Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts.

Publication ,  Journal Article
Friedman, HS; Houghton, PJ; Schold, SC; Keir, S; Bigner, DD
Published in: Cancer Chemother Pharmacol
1994

The activity of dimethylaminomethyl-10-hydroxycamptothecin (topotecan) was evaluated against a panel of xenografts derived from ependymomas (D528 EP, D612 EP), childhood high-grade gliomas (D-456 MG, D-212 MG), adult high-grade gliomas (D-245 MG, D-54 MG), and medulloblastomas (D425 Med) growing s.c. and i.c. (intracranially) in athymic nude mice. Topotecan was given at a dose of 1.9 mg/kg by i.p. injection in 0.9% saline using a volume of 90 ml/m2 on days 1-5 and 8-12, which represents the dose lethal to 10% of treated animals. Topotecan was active in the therapy of all s.c. xenografts tested, with growth delays ranging from 6.3 days in D-54 MG to 55.7 days in D528 EP. Topotecan produced statistically significant tumor regressions in D425 Med, D-456 MG, D-245 MG, D528 EP, and D612 EP. No tumor regression was seen in any control animal. Statistically significant increases in median survival were seen in the two i.c. xenografts--D-456 MG (28.6% increase) and D-54 MG (39% increase)--treated with topotecan. These studies suggest that topotecan may be an important new addition to the therapy of central nervous system tumors.

Duke Scholars

Published In

Cancer Chemother Pharmacol

DOI

ISSN

0344-5704

Publication Date

1994

Volume

34

Issue

2

Start / End Page

171 / 174

Location

Germany

Related Subject Headings

  • Transplantation, Heterologous
  • Topotecan
  • Time Factors
  • Random Allocation
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Mice, Inbred BALB C
  • Mice
  • Humans
  • Female
 

Citation

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Chicago
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MLA
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Friedman, H. S., Houghton, P. J., Schold, S. C., Keir, S., & Bigner, D. D. (1994). Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts. Cancer Chemother Pharmacol, 34(2), 171–174. https://doi.org/10.1007/BF00685936
Friedman, H. S., P. J. Houghton, S. C. Schold, S. Keir, and D. D. Bigner. “Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts.Cancer Chemother Pharmacol 34, no. 2 (1994): 171–74. https://doi.org/10.1007/BF00685936.
Friedman HS, Houghton PJ, Schold SC, Keir S, Bigner DD. Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts. Cancer Chemother Pharmacol. 1994;34(2):171–4.
Friedman, H. S., et al. “Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts.Cancer Chemother Pharmacol, vol. 34, no. 2, 1994, pp. 171–74. Pubmed, doi:10.1007/BF00685936.
Friedman HS, Houghton PJ, Schold SC, Keir S, Bigner DD. Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts. Cancer Chemother Pharmacol. 1994;34(2):171–174.
Journal cover image

Published In

Cancer Chemother Pharmacol

DOI

ISSN

0344-5704

Publication Date

1994

Volume

34

Issue

2

Start / End Page

171 / 174

Location

Germany

Related Subject Headings

  • Transplantation, Heterologous
  • Topotecan
  • Time Factors
  • Random Allocation
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Mice, Inbred BALB C
  • Mice
  • Humans
  • Female