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L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice.

Publication ,  Journal Article
Lippitz, BE; Halperin, EC; Griffith, OW; Colvin, OM; Honore, G; Ostertag, CB; Bigner, DD; Friedman, HS
Published in: Neurosurgery
February 1990

An intracranial (i.c.) interstitial radiotherapy model in athymic nude mice bearing i.c. D-54 MG human glioma xenografts was developed, allowing evaluation of the therapeutic benefits seen after L-buthionine-S,R-sulfoximine (L-BSO)-mediated depletion of tumor glutathione levels. Administration of L-BSO [2.5 mmol/kg intraperitoneal injections x 4 doses plus concomitant availability in acidified (pH 3.0) drinking water at a concentration of 20 mM] resulted in depletion of tumor glutathione levels to 0.15 mumol/g wet weight (7.9% of control). The therapeutic activity of i.c. interstitial radiotherapy with an 125I seed was enhanced after L-BSO-mediated glutathione depletion, with increases in median survival of 13.4 to 30.5% over that seen with 125I seeds alone. These studies demonstrate a potential role for BSO in enhancing the therapeutic activity of interstitial radiotherapy.

Duke Scholars

Published In

Neurosurgery

DOI

ISSN

0148-396X

Publication Date

February 1990

Volume

26

Issue

2

Start / End Page

255 / 260

Location

United States

Related Subject Headings

  • Radiation-Sensitizing Agents
  • Neurology & Neurosurgery
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice, Inbred BALB C
  • Mice
  • Methionine Sulfoximine
  • Male
  • Glioma
  • Buthionine Sulfoximine
 

Citation

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MLA
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Lippitz, B. E., Halperin, E. C., Griffith, O. W., Colvin, O. M., Honore, G., Ostertag, C. B., … Friedman, H. S. (1990). L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice. Neurosurgery, 26(2), 255–260. https://doi.org/10.1097/00006123-199002000-00012
Lippitz, B. E., E. C. Halperin, O. W. Griffith, O. M. Colvin, G. Honore, C. B. Ostertag, D. D. Bigner, and H. S. Friedman. “L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice.Neurosurgery 26, no. 2 (February 1990): 255–60. https://doi.org/10.1097/00006123-199002000-00012.
Lippitz BE, Halperin EC, Griffith OW, Colvin OM, Honore G, Ostertag CB, et al. L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice. Neurosurgery. 1990 Feb;26(2):255–60.
Lippitz, B. E., et al. “L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice.Neurosurgery, vol. 26, no. 2, Feb. 1990, pp. 255–60. Pubmed, doi:10.1097/00006123-199002000-00012.
Lippitz BE, Halperin EC, Griffith OW, Colvin OM, Honore G, Ostertag CB, Bigner DD, Friedman HS. L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice. Neurosurgery. 1990 Feb;26(2):255–260.
Journal cover image

Published In

Neurosurgery

DOI

ISSN

0148-396X

Publication Date

February 1990

Volume

26

Issue

2

Start / End Page

255 / 260

Location

United States

Related Subject Headings

  • Radiation-Sensitizing Agents
  • Neurology & Neurosurgery
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice, Inbred BALB C
  • Mice
  • Methionine Sulfoximine
  • Male
  • Glioma
  • Buthionine Sulfoximine