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Immunohistochemical detection of factor VIII/von Willebrand factor in hyperplastic endothelial cells in glioblastoma multiforme and mixed glioma-sarcoma.

Publication ,  Journal Article
McComb, RD; Jones, TR; Pizzo, SV; Bigner, DD
Published in: J Neuropathol Exp Neurol
September 1982

The sarcomatous components of most glioma-sarcomas are thought to arise from the neoplastic transformation of hyperplastic endothelial and adventitial vascular cells in a preexisting glioblastoma multiforme. The expression of factor VIII/von Willebrand factor (FVIII/vWF), a marker for endothelial cells, and of glial fibrillary acidic protein (GFAP), a marker for glial cells, was examined in 10 glioblastomas and seven mixed glioma-sarcomas using the peroxidase-antiperoxidase immunohistochemical technique. Hyperplasia of small blood vessels was observed in all 10 glioblastomas; in five, the vascular proliferation had resulted in the formation of prominent glomeruloid structures. FVIII/vWF was detected in the endothelial cells in these vascular structures, but not in the adventitial cells. In the mixed glioma-sarcomas. FVIII/vWF was detected only in endothelial cells; there was no staining for FVIII/vWF in the neoplastic mesenchymal cells. The gliomatous components of the mixed tumors stained intensely for GFAP. These observations indicate that both endothelial and nonendothelial cell types contribute to the small vessel hyperplasia in glioblastomas, and that the sarcomatous components of mixed glioma-sarcomas are derived from either non-endothelial cells or endothelial cells that have undergone antigenic loss following transformation.

Duke Scholars

Published In

J Neuropathol Exp Neurol

ISSN

0022-3069

Publication Date

September 1982

Volume

41

Issue

5

Start / End Page

479 / 489

Location

England

Related Subject Headings

  • von Willebrand Factor
  • Sarcoma
  • Neurology & Neurosurgery
  • Nerve Tissue Proteins
  • Middle Aged
  • Male
  • Hyperplasia
  • Humans
  • Glioma
  • Glioblastoma
 

Citation

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McComb, R. D., Jones, T. R., Pizzo, S. V., & Bigner, D. D. (1982). Immunohistochemical detection of factor VIII/von Willebrand factor in hyperplastic endothelial cells in glioblastoma multiforme and mixed glioma-sarcoma. J Neuropathol Exp Neurol, 41(5), 479–489.
McComb, R. D., T. R. Jones, S. V. Pizzo, and D. D. Bigner. “Immunohistochemical detection of factor VIII/von Willebrand factor in hyperplastic endothelial cells in glioblastoma multiforme and mixed glioma-sarcoma.J Neuropathol Exp Neurol 41, no. 5 (September 1982): 479–89.
Journal cover image

Published In

J Neuropathol Exp Neurol

ISSN

0022-3069

Publication Date

September 1982

Volume

41

Issue

5

Start / End Page

479 / 489

Location

England

Related Subject Headings

  • von Willebrand Factor
  • Sarcoma
  • Neurology & Neurosurgery
  • Nerve Tissue Proteins
  • Middle Aged
  • Male
  • Hyperplasia
  • Humans
  • Glioma
  • Glioblastoma