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Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice.

Publication ,  Journal Article
Poss, KD; Thomas, MJ; Ebralidze, AK; O'Dell, TJ; Tonegawa, S
Published in: Neuron
October 1995

We have generated mice deficient in HO-2, the major cerebral isoform of heme oxygenase, in order to assess the potential role of carbon monoxide as a retrograde messenger in hippocampal LTP. Cerebral HO catalytic activity was markedly reduced in the HO-2 mutant mice, yet no differences were found between wild types and mutants in gross neuroanatomical structure, in basal hippocampal synaptic transmission, or in the amount of potentiation produced by various LTP induction protocols. Furthermore, zinc protoporphyrin IX, an inhibitor of HO, had nearly identical inhibitory effects on LTP in wild-type and HO-2 mutant hippocampal slices. Our data indicate that carbon monoxide produced endogenously by HO is unlikely to be a neuromodulator required for LTP in the hippocampus.

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Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

October 1995

Volume

15

Issue

4

Start / End Page

867 / 873

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Rats
  • Protoporphyrins
  • Neurology & Neurosurgery
  • Mutagenesis
  • Mice, Mutant Strains
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Long-Term Potentiation
 

Citation

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ICMJE
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Poss, K. D., Thomas, M. J., Ebralidze, A. K., O’Dell, T. J., & Tonegawa, S. (1995). Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. Neuron, 15(4), 867–873. https://doi.org/10.1016/0896-6273(95)90177-9
Poss, K. D., M. J. Thomas, A. K. Ebralidze, T. J. O’Dell, and S. Tonegawa. “Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice.Neuron 15, no. 4 (October 1995): 867–73. https://doi.org/10.1016/0896-6273(95)90177-9.
Poss KD, Thomas MJ, Ebralidze AK, O’Dell TJ, Tonegawa S. Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. Neuron. 1995 Oct;15(4):867–73.
Poss, K. D., et al. “Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice.Neuron, vol. 15, no. 4, Oct. 1995, pp. 867–73. Pubmed, doi:10.1016/0896-6273(95)90177-9.
Poss KD, Thomas MJ, Ebralidze AK, O’Dell TJ, Tonegawa S. Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. Neuron. 1995 Oct;15(4):867–873.
Journal cover image

Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

October 1995

Volume

15

Issue

4

Start / End Page

867 / 873

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Rats
  • Protoporphyrins
  • Neurology & Neurosurgery
  • Mutagenesis
  • Mice, Mutant Strains
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Long-Term Potentiation