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Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury.

Publication ,  Journal Article
Rinder, CS; Fontes, M; Mathew, JP; Rinder, HM; Smith, BR; Multicenter Study of Perioperative Ischemia Research Group,
Published in: Ann Thorac Surg
March 2003

BACKGROUND: Renal injury remains a persistent complication of cardiopulmonary bypass (CPB) that, when sufficient to require dialysis, increases mortality eight-fold. The high prevalence of renal failure in sepsis and adult respiratory distress syndrome has been linked to the systemic inflammatory response associated with those disorders. We hypothesized that components of the inflammatory response to CPB may similarly contribute to post-CPB acute renal injury. METHODS: Markers of leukocyte and platelet activation peri-CPB were measured in 75 patients undergoing cardiac operation with CPB and were correlated with acute renal injury, defined as an increase (> or = 50%) in peak serum creatinine post-CPB. RESULTS: Eleven patients sustained post-CPB acute renal injury. This subset of patients demonstrated significantly greater increases in neutrophil CD11b density (p = 0.01), as well as higher total neutrophil counts (p = 0.045), compared with patients with preserved renal function. Hemodynamic instability sufficient to require postoperative hemodynamic support also predicted an increased risk of acute renal injury. However, neutrophil CD11b upregulation did not correlate with this or any other clinical variables associated with renal risk, suggesting that this marker of the neutrophil inflammatory response may independently predict renal injury. By contrast other inflammatory markers, neutrophil myeloperoxidase levels, monocyte CD11b, base line C-reactive protein, and platelet CD62P expression did not differ between the two patient groups. CONCLUSIONS: Upregulation of the neutrophil adhesion receptor CD11b and high circulating neutrophil numbers are associated with acute renal injury after CPB, suggesting a contribution by activated neutrophils to the pathophysiology of this complication.

Duke Scholars

Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

March 2003

Volume

75

Issue

3

Start / End Page

899 / 905

Location

Netherlands

Related Subject Headings

  • Systemic Inflammatory Response Syndrome
  • Risk Factors
  • Respiratory System
  • Prospective Studies
  • Postoperative Complications
  • Neutrophils
  • Middle Aged
  • Leukocyte Count
  • Intra-Aortic Balloon Pumping
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rinder, C. S., Fontes, M., Mathew, J. P., Rinder, H. M., Smith, B. R., & Multicenter Study of Perioperative Ischemia Research Group, . (2003). Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury. Ann Thorac Surg, 75(3), 899–905. https://doi.org/10.1016/s0003-4975(02)04490-9
Rinder, Christine S., Manuel Fontes, Joseph P. Mathew, Henry M. Rinder, Brian R. Smith, and Brian R. Multicenter Study of Perioperative Ischemia Research Group. “Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury.Ann Thorac Surg 75, no. 3 (March 2003): 899–905. https://doi.org/10.1016/s0003-4975(02)04490-9.
Rinder CS, Fontes M, Mathew JP, Rinder HM, Smith BR, Multicenter Study of Perioperative Ischemia Research Group. Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury. Ann Thorac Surg. 2003 Mar;75(3):899–905.
Rinder, Christine S., et al. “Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury.Ann Thorac Surg, vol. 75, no. 3, Mar. 2003, pp. 899–905. Pubmed, doi:10.1016/s0003-4975(02)04490-9.
Rinder CS, Fontes M, Mathew JP, Rinder HM, Smith BR, Multicenter Study of Perioperative Ischemia Research Group. Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury. Ann Thorac Surg. 2003 Mar;75(3):899–905.
Journal cover image

Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

March 2003

Volume

75

Issue

3

Start / End Page

899 / 905

Location

Netherlands

Related Subject Headings

  • Systemic Inflammatory Response Syndrome
  • Risk Factors
  • Respiratory System
  • Prospective Studies
  • Postoperative Complications
  • Neutrophils
  • Middle Aged
  • Leukocyte Count
  • Intra-Aortic Balloon Pumping
  • Humans