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Migration of mesonephric cells into the mammalian gonad depends on Sry.

Publication ,  Journal Article
Capel, B; Albrecht, KH; Washburn, LL; Eicher, EM
Published in: Mech Dev
June 1999

In mammals, the primary step in male sex determination is the initiation of testis development which depends on the expression of the Y-linked testis determining gene, Sry. The mechanisms by which Sry controls this process are unknown. Studies showed that cell migration from the adjacent mesonephros only occurs into XY gonads; however, it was not known whether this effect depended on Sry, another Y-linked gene, or the presence of one versus two X chromosomes. Here we provide genetic proof that Sry is the only Y-linked gene necessary for cell migration into the gonad. Cell migration from the mesonephros into the differentiating gonad is consistently associated with Sty's presence and with testis cord formation, suggesting that cell migration plays a critical role in the initiation of testis cord development. The induction of cell migration represents the earliest signaling pathway yet assigned to Sry.

Duke Scholars

Published In

Mech Dev

DOI

ISSN

0925-4773

Publication Date

June 1999

Volume

84

Issue

1-2

Start / End Page

127 / 131

Location

Ireland

Related Subject Headings

  • Y Chromosome
  • Transcription Factors
  • Testis
  • Sex-Determining Region Y Protein
  • Organ Culture Techniques
  • Nuclear Proteins
  • Mice, Transgenic
  • Mice, Inbred Strains
  • Mice
  • Mesonephros
 

Citation

APA
Chicago
ICMJE
MLA
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Capel, B., Albrecht, K. H., Washburn, L. L., & Eicher, E. M. (1999). Migration of mesonephric cells into the mammalian gonad depends on Sry. Mech Dev, 84(1–2), 127–131. https://doi.org/10.1016/s0925-4773(99)00047-7
Capel, B., K. H. Albrecht, L. L. Washburn, and E. M. Eicher. “Migration of mesonephric cells into the mammalian gonad depends on Sry.Mech Dev 84, no. 1–2 (June 1999): 127–31. https://doi.org/10.1016/s0925-4773(99)00047-7.
Capel B, Albrecht KH, Washburn LL, Eicher EM. Migration of mesonephric cells into the mammalian gonad depends on Sry. Mech Dev. 1999 Jun;84(1–2):127–31.
Capel, B., et al. “Migration of mesonephric cells into the mammalian gonad depends on Sry.Mech Dev, vol. 84, no. 1–2, June 1999, pp. 127–31. Pubmed, doi:10.1016/s0925-4773(99)00047-7.
Capel B, Albrecht KH, Washburn LL, Eicher EM. Migration of mesonephric cells into the mammalian gonad depends on Sry. Mech Dev. 1999 Jun;84(1–2):127–131.
Journal cover image

Published In

Mech Dev

DOI

ISSN

0925-4773

Publication Date

June 1999

Volume

84

Issue

1-2

Start / End Page

127 / 131

Location

Ireland

Related Subject Headings

  • Y Chromosome
  • Transcription Factors
  • Testis
  • Sex-Determining Region Y Protein
  • Organ Culture Techniques
  • Nuclear Proteins
  • Mice, Transgenic
  • Mice, Inbred Strains
  • Mice
  • Mesonephros