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Male-to-female sex reversal in mice lacking fibroblast growth factor 9.

Publication ,  Journal Article
Colvin, JS; Green, RP; Schmahl, J; Capel, B; Ornitz, DM
Published in: Cell
March 23, 2001

Fgfs direct embryogenesis of several organs, including the lung, limb, and anterior pituitary. Here we report male-to-female sex reversal in mice lacking Fibroblast growth factor 9 (Fgf9), demonstrating a novel role for FGF signaling in testicular embryogenesis. Fgf9(-/-) mice also exhibit lung hypoplasia and die at birth. Reproductive system phenotypes range from testicular hypoplasia to complete sex reversal, with most Fgf9(-/-) XY reproductive systems appearing grossly female at birth. Fgf9 appears to act downstream of Sry to stimulate mesenchymal proliferation, mesonephric cell migration, and Sertoli cell differentiation in the embryonic testis. While Sry is found only in some mammals, Fgfs are highly conserved. Thus, Fgfs may function in sex determination and reproductive system development in many species.

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Published In

Cell

DOI

ISSN

0092-8674

Publication Date

March 23, 2001

Volume

104

Issue

6

Start / End Page

875 / 889

Location

United States

Related Subject Headings

  • Transcription Factors
  • Testis
  • Sex Differentiation
  • SOX9 Transcription Factor
  • Restriction Mapping
  • Ovary
  • Mice, Knockout
  • Mice
  • Male
  • High Mobility Group Proteins
 

Citation

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Colvin, J. S., Green, R. P., Schmahl, J., Capel, B., & Ornitz, D. M. (2001). Male-to-female sex reversal in mice lacking fibroblast growth factor 9. Cell, 104(6), 875–889. https://doi.org/10.1016/s0092-8674(01)00284-7
Colvin, J. S., R. P. Green, J. Schmahl, B. Capel, and D. M. Ornitz. “Male-to-female sex reversal in mice lacking fibroblast growth factor 9.Cell 104, no. 6 (March 23, 2001): 875–89. https://doi.org/10.1016/s0092-8674(01)00284-7.
Colvin JS, Green RP, Schmahl J, Capel B, Ornitz DM. Male-to-female sex reversal in mice lacking fibroblast growth factor 9. Cell. 2001 Mar 23;104(6):875–89.
Colvin, J. S., et al. “Male-to-female sex reversal in mice lacking fibroblast growth factor 9.Cell, vol. 104, no. 6, Mar. 2001, pp. 875–89. Pubmed, doi:10.1016/s0092-8674(01)00284-7.
Colvin JS, Green RP, Schmahl J, Capel B, Ornitz DM. Male-to-female sex reversal in mice lacking fibroblast growth factor 9. Cell. 2001 Mar 23;104(6):875–889.
Journal cover image

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

March 23, 2001

Volume

104

Issue

6

Start / End Page

875 / 889

Location

United States

Related Subject Headings

  • Transcription Factors
  • Testis
  • Sex Differentiation
  • SOX9 Transcription Factor
  • Restriction Mapping
  • Ovary
  • Mice, Knockout
  • Mice
  • Male
  • High Mobility Group Proteins