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Cellular and molecular pathways regulating mammalian sex determination.

Publication ,  Journal Article
Tilmann, C; Capel, B
Published in: Recent Prog Horm Res
2002

In mammals, sex is determined by the presence or absence of a single gene on the Y chromosome, Sry. Sry, a member of the high mobility group family of transcription factors, is required to initiate male-specific pathways and repress female-specific pathways. Expression of Sry in the gonad, beginning at 10.5 days postcoitum, leads to the differentiation of the somatic supporting cell precursors as Sertoli cells. These cells direct the other cells of the gonad into their respective lineages. Currently, no direct targets of Sry are known. A number of cellular pathways initiated by Sry are required for testis development. These include the proliferation of pre-Sertoli cells and commitment to the Sertoli lineage, migration of cells from the adjacent mesonephros, and formation of a male-specific vasculature. Work is underway to identify genes controlling these processes. These genes will then be linked to Sry.

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Published In

Recent Prog Horm Res

DOI

ISSN

0079-9963

Publication Date

2002

Volume

57

Start / End Page

1 / 18

Location

United States

Related Subject Headings

  • Y Chromosome
  • Testis
  • Sex Determination Processes
  • Ovary
  • Male
  • Gonads
  • Genes, sry
  • Female
  • Endocrinology & Metabolism
  • Cell Differentiation
 

Citation

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Tilmann, C., & Capel, B. (2002). Cellular and molecular pathways regulating mammalian sex determination. Recent Prog Horm Res, 57, 1–18. https://doi.org/10.1210/rp.57.1.1
Tilmann, Christopher, and Blanche Capel. “Cellular and molecular pathways regulating mammalian sex determination.Recent Prog Horm Res 57 (2002): 1–18. https://doi.org/10.1210/rp.57.1.1.
Tilmann C, Capel B. Cellular and molecular pathways regulating mammalian sex determination. Recent Prog Horm Res. 2002;57:1–18.
Tilmann, Christopher, and Blanche Capel. “Cellular and molecular pathways regulating mammalian sex determination.Recent Prog Horm Res, vol. 57, 2002, pp. 1–18. Pubmed, doi:10.1210/rp.57.1.1.
Tilmann C, Capel B. Cellular and molecular pathways regulating mammalian sex determination. Recent Prog Horm Res. 2002;57:1–18.

Published In

Recent Prog Horm Res

DOI

ISSN

0079-9963

Publication Date

2002

Volume

57

Start / End Page

1 / 18

Location

United States

Related Subject Headings

  • Y Chromosome
  • Testis
  • Sex Determination Processes
  • Ovary
  • Male
  • Gonads
  • Genes, sry
  • Female
  • Endocrinology & Metabolism
  • Cell Differentiation