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Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad.

Publication ,  Journal Article
Jeays-Ward, K; Hoyle, C; Brennan, J; Dandonneau, M; Alldus, G; Capel, B; Swain, A
Published in: Development
August 2003

The signalling molecule WNT4 has been associated with sex reversal phenotypes in mammals. Here we show that the role of WNT4 in gonad development is to pattern the sex-specific vasculature and to regulate steroidogenic cell recruitment. Vascular formation and steroid production in the mammalian gonad occur in a sex-specific manner. During testis development, endothelial cells migrate from the mesonephros into the gonad to form a coelomic blood vessel. Leydig cells differentiate and produce steroid hormones a day later. Neither of these events occurs in the XX gonad. We show that WNT4 represses mesonephric endothelial and steroidogenic cell migration in the XX gonad, preventing the formation of a male-specific coelomic blood vessel and the production of steroids. In the XY gonad, Wnt4 expression is downregulated after sex determination. Transgenic misexpression of Wnt4 in the embryonic testis did not inhibit coelomic vessel formation but vascular pattern was affected. Leydig cell differentiation was not affected in these transgenic animals and our data implies that Wnt4 does not regulate steroidogenic cell differentiation but represses the migration of steroidogenic adrenal precursors into the gonad. These studies provide a model for understanding how the same signalling molecule can act on two different cell types to coordinate sex development.

Duke Scholars

Published In

Development

DOI

ISSN

0950-1991

Publication Date

August 2003

Volume

130

Issue

16

Start / End Page

3663 / 3670

Location

England

Related Subject Headings

  • Wnt4 Protein
  • Wnt Proteins
  • Testis
  • Sex Determination Processes
  • Sex Chromosomes
  • Proto-Oncogene Proteins
  • Mice, Transgenic
  • Mice
  • Male
  • In Situ Hybridization
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jeays-Ward, K., Hoyle, C., Brennan, J., Dandonneau, M., Alldus, G., Capel, B., & Swain, A. (2003). Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. Development, 130(16), 3663–3670. https://doi.org/10.1242/dev.00591
Jeays-Ward, Katherine, Christine Hoyle, Jennifer Brennan, Mathieu Dandonneau, Graham Alldus, Blanche Capel, and Amanda Swain. “Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad.Development 130, no. 16 (August 2003): 3663–70. https://doi.org/10.1242/dev.00591.
Jeays-Ward K, Hoyle C, Brennan J, Dandonneau M, Alldus G, Capel B, et al. Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. Development. 2003 Aug;130(16):3663–70.
Jeays-Ward, Katherine, et al. “Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad.Development, vol. 130, no. 16, Aug. 2003, pp. 3663–70. Pubmed, doi:10.1242/dev.00591.
Jeays-Ward K, Hoyle C, Brennan J, Dandonneau M, Alldus G, Capel B, Swain A. Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. Development. 2003 Aug;130(16):3663–3670.
Journal cover image

Published In

Development

DOI

ISSN

0950-1991

Publication Date

August 2003

Volume

130

Issue

16

Start / End Page

3663 / 3670

Location

England

Related Subject Headings

  • Wnt4 Protein
  • Wnt Proteins
  • Testis
  • Sex Determination Processes
  • Sex Chromosomes
  • Proto-Oncogene Proteins
  • Mice, Transgenic
  • Mice
  • Male
  • In Situ Hybridization