![Journal cover image](https://secure.syndetics.com/index.aspx?isbn=/lc.gif&issn=0950-1991&client=dukeuniv)
Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination.
Publication
, Journal Article
Schmahl, J; Kim, Y; Colvin, JS; Ornitz, DM; Capel, B
Published in: Development
August 2004
Recently, we demonstrated that loss of Fgf9 results in a block of testis development and a male to female sex-reversed phenotype; however, the function of Fgf9 in sex determination was unknown. We now show that Fgf9 is necessary for two steps of testis development just downstream of the male sex-determining gene, Sry: (1) for the proliferation of a population of cells that give rise to Sertoli progenitors; and (2) for the nuclear localization of an FGF receptor (FGFR2) in Sertoli cell precursors. The nuclear localization of FGFR2 coincides with the initiation of Sry expression and the nuclear localization of SOX9 during the early differentiation of Sertoli cells and the determination of male fate.
Duke Scholars
Published In
Development
DOI
ISSN
0950-1991
Publication Date
August 2004
Volume
131
Issue
15
Start / End Page
3627 / 3636
Location
England
Related Subject Headings
- Transcription Factors
- Testis
- Sex-Determining Region Y Protein
- Sex Differentiation
- Sex Determination Processes
- Sex Chromosomes
- Sertoli Cells
- SOX9 Transcription Factor
- Recombinant Fusion Proteins
- Receptors, Fibroblast Growth Factor
Citation
APA
Chicago
ICMJE
MLA
NLM
Schmahl, J., Kim, Y., Colvin, J. S., Ornitz, D. M., & Capel, B. (2004). Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development, 131(15), 3627–3636. https://doi.org/10.1242/dev.01239
Schmahl, Jennifer, Yuna Kim, Jennifer S. Colvin, David M. Ornitz, and Blanche Capel. “Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination.” Development 131, no. 15 (August 2004): 3627–36. https://doi.org/10.1242/dev.01239.
Schmahl J, Kim Y, Colvin JS, Ornitz DM, Capel B. Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development. 2004 Aug;131(15):3627–36.
Schmahl, Jennifer, et al. “Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination.” Development, vol. 131, no. 15, Aug. 2004, pp. 3627–36. Pubmed, doi:10.1242/dev.01239.
Schmahl J, Kim Y, Colvin JS, Ornitz DM, Capel B. Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development. 2004 Aug;131(15):3627–3636.
![Journal cover image](https://secure.syndetics.com/index.aspx?isbn=/lc.gif&issn=0950-1991&client=dukeuniv)
Published In
Development
DOI
ISSN
0950-1991
Publication Date
August 2004
Volume
131
Issue
15
Start / End Page
3627 / 3636
Location
England
Related Subject Headings
- Transcription Factors
- Testis
- Sex-Determining Region Y Protein
- Sex Differentiation
- Sex Determination Processes
- Sex Chromosomes
- Sertoli Cells
- SOX9 Transcription Factor
- Recombinant Fusion Proteins
- Receptors, Fibroblast Growth Factor