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Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination.

Publication ,  Journal Article
Schmahl, J; Kim, Y; Colvin, JS; Ornitz, DM; Capel, B
Published in: Development
August 2004

Recently, we demonstrated that loss of Fgf9 results in a block of testis development and a male to female sex-reversed phenotype; however, the function of Fgf9 in sex determination was unknown. We now show that Fgf9 is necessary for two steps of testis development just downstream of the male sex-determining gene, Sry: (1) for the proliferation of a population of cells that give rise to Sertoli progenitors; and (2) for the nuclear localization of an FGF receptor (FGFR2) in Sertoli cell precursors. The nuclear localization of FGFR2 coincides with the initiation of Sry expression and the nuclear localization of SOX9 during the early differentiation of Sertoli cells and the determination of male fate.

Duke Scholars

Published In

Development

DOI

ISSN

0950-1991

Publication Date

August 2004

Volume

131

Issue

15

Start / End Page

3627 / 3636

Location

England

Related Subject Headings

  • Transcription Factors
  • Testis
  • Sex-Determining Region Y Protein
  • Sex Differentiation
  • Sex Determination Processes
  • Sex Chromosomes
  • Sertoli Cells
  • SOX9 Transcription Factor
  • Recombinant Fusion Proteins
  • Receptors, Fibroblast Growth Factor
 

Citation

APA
Chicago
ICMJE
MLA
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Schmahl, J., Kim, Y., Colvin, J. S., Ornitz, D. M., & Capel, B. (2004). Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development, 131(15), 3627–3636. https://doi.org/10.1242/dev.01239
Schmahl, Jennifer, Yuna Kim, Jennifer S. Colvin, David M. Ornitz, and Blanche Capel. “Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination.Development 131, no. 15 (August 2004): 3627–36. https://doi.org/10.1242/dev.01239.
Schmahl J, Kim Y, Colvin JS, Ornitz DM, Capel B. Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development. 2004 Aug;131(15):3627–36.
Schmahl, Jennifer, et al. “Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination.Development, vol. 131, no. 15, Aug. 2004, pp. 3627–36. Pubmed, doi:10.1242/dev.01239.
Schmahl J, Kim Y, Colvin JS, Ornitz DM, Capel B. Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development. 2004 Aug;131(15):3627–3636.
Journal cover image

Published In

Development

DOI

ISSN

0950-1991

Publication Date

August 2004

Volume

131

Issue

15

Start / End Page

3627 / 3636

Location

England

Related Subject Headings

  • Transcription Factors
  • Testis
  • Sex-Determining Region Y Protein
  • Sex Differentiation
  • Sex Determination Processes
  • Sex Chromosomes
  • Sertoli Cells
  • SOX9 Transcription Factor
  • Recombinant Fusion Proteins
  • Receptors, Fibroblast Growth Factor