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Signaling at the crossroads of gonad development.

Publication ,  Journal Article
Ross, AJ; Capel, B
Published in: Trends Endocrinol Metab
2005

In mammals, the gonads arise as bipotential primordia that are capable of developing as either testes or ovaries. Expression of the Y-linked gene Sry in the XY gonad initiates testis differentiation; in the absence of Sry, ovarian pathways prevail. Although the molecular targets of SRY are not known, many of the early cellular and morphological events that occur downstream of Sry have been characterized. These include increased cell proliferation, Sertoli cell differentiation, testis cord formation, development of a testis-specific vasculature and differentiation of interstitial lineages. Recently, several of the molecular signals that direct these processes have been identified. In addition, the pathways that suppress features of testis development in the XX gonad are being elucidated.

Duke Scholars

Published In

Trends Endocrinol Metab

DOI

ISSN

1043-2760

Publication Date

2005

Volume

16

Issue

1

Start / End Page

19 / 25

Location

United States

Related Subject Headings

  • Signal Transduction
  • Sex Characteristics
  • Sertoli Cells
  • Rats
  • Mice
  • Male
  • Leydig Cells
  • Humans
  • Gonads
  • Germ Cells
 

Citation

APA
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ICMJE
MLA
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Ross, A. J., & Capel, B. (2005). Signaling at the crossroads of gonad development. Trends Endocrinol Metab, 16(1), 19–25. https://doi.org/10.1016/j.tem.2004.11.004
Ross, Andrea J., and Blanche Capel. “Signaling at the crossroads of gonad development.Trends Endocrinol Metab 16, no. 1 (2005): 19–25. https://doi.org/10.1016/j.tem.2004.11.004.
Ross AJ, Capel B. Signaling at the crossroads of gonad development. Trends Endocrinol Metab. 2005;16(1):19–25.
Ross, Andrea J., and Blanche Capel. “Signaling at the crossroads of gonad development.Trends Endocrinol Metab, vol. 16, no. 1, 2005, pp. 19–25. Pubmed, doi:10.1016/j.tem.2004.11.004.
Ross AJ, Capel B. Signaling at the crossroads of gonad development. Trends Endocrinol Metab. 2005;16(1):19–25.
Journal cover image

Published In

Trends Endocrinol Metab

DOI

ISSN

1043-2760

Publication Date

2005

Volume

16

Issue

1

Start / End Page

19 / 25

Location

United States

Related Subject Headings

  • Signal Transduction
  • Sex Characteristics
  • Sertoli Cells
  • Rats
  • Mice
  • Male
  • Leydig Cells
  • Humans
  • Gonads
  • Germ Cells