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Do prolonged febrile seizures produce medial temporal sclerosis? Hypotheses, MRI evidence and unanswered questions.

Publication ,  Journal Article
Lewis, DV; Barboriak, DP; MacFall, JR; Provenzale, JM; Mitchell, TV; VanLandingham, KE
Published in: Prog Brain Res
2002

Whether or not severe febrile seizures in infancy cause hippocampal injury and subsequent medial temporal sclerosis is an often debated question in epilepsy. Recent magnetic resonance imaging (MRI) of infants suffering from febrile seizures has provided preliminary evidence that abnormally increased T2 signal intensity can be seen in the hippocampi of infants following prolonged and focal febrile seizures. Follow-up MRIs in a few of these infants have confirmed that medial temporal sclerosis can develop following these acute MRI signal changes. In this article, we review the hypotheses and MRI evidence relating to hippocampal injury during prolonged febrile seizures and the later development of medial temporal sclerosis.

Duke Scholars

Published In

Prog Brain Res

DOI

ISSN

0079-6123

Publication Date

2002

Volume

135

Start / End Page

263 / 278

Location

Netherlands

Related Subject Headings

  • Temporal Lobe
  • Seizures, Febrile
  • Seizures
  • Sclerosis
  • Neurology & Neurosurgery
  • Magnetic Resonance Imaging
  • Humans
  • Hippocampus
  • Epilepsy
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lewis, D. V., Barboriak, D. P., MacFall, J. R., Provenzale, J. M., Mitchell, T. V., & VanLandingham, K. E. (2002). Do prolonged febrile seizures produce medial temporal sclerosis? Hypotheses, MRI evidence and unanswered questions. Prog Brain Res, 135, 263–278. https://doi.org/10.1016/s0079-6123(02)35025-8
Lewis, Darrell V., Daniel P. Barboriak, James R. MacFall, James M. Provenzale, Teresa V. Mitchell, and Kevan E. VanLandingham. “Do prolonged febrile seizures produce medial temporal sclerosis? Hypotheses, MRI evidence and unanswered questions.Prog Brain Res 135 (2002): 263–78. https://doi.org/10.1016/s0079-6123(02)35025-8.
Lewis DV, Barboriak DP, MacFall JR, Provenzale JM, Mitchell TV, VanLandingham KE. Do prolonged febrile seizures produce medial temporal sclerosis? Hypotheses, MRI evidence and unanswered questions. Prog Brain Res. 2002;135:263–78.
Lewis, Darrell V., et al. “Do prolonged febrile seizures produce medial temporal sclerosis? Hypotheses, MRI evidence and unanswered questions.Prog Brain Res, vol. 135, 2002, pp. 263–78. Pubmed, doi:10.1016/s0079-6123(02)35025-8.
Lewis DV, Barboriak DP, MacFall JR, Provenzale JM, Mitchell TV, VanLandingham KE. Do prolonged febrile seizures produce medial temporal sclerosis? Hypotheses, MRI evidence and unanswered questions. Prog Brain Res. 2002;135:263–278.
Journal cover image

Published In

Prog Brain Res

DOI

ISSN

0079-6123

Publication Date

2002

Volume

135

Start / End Page

263 / 278

Location

Netherlands

Related Subject Headings

  • Temporal Lobe
  • Seizures, Febrile
  • Seizures
  • Sclerosis
  • Neurology & Neurosurgery
  • Magnetic Resonance Imaging
  • Humans
  • Hippocampus
  • Epilepsy
  • Animals