Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.
Publication
, Journal Article
Meador, WE; Means, AR; Quiocho, FA
Published in: Science
December 10, 1993
Calmodulin is the primary calcium-dependent signal transducer and regulator of a wide variety of essential cellular functions. The structure of calcium-calmodulin bound to the peptide corresponding to the calmodulin-binding domain of brain calmodulin-dependent protein kinase II alpha was determined to 2 angstrom resolution. A comparison to two other calcium-calmodulin structures reveals how the central helix unwinds in order to position the two domains optimally in the recognition of different target enzymes and clarifies the role of calcium in maintaining recognition-competent domain structures.
Duke Scholars
Published In
Science
DOI
ISSN
0036-8075
Publication Date
December 10, 1993
Volume
262
Issue
5140
Start / End Page
1718 / 1721
Location
United States
Related Subject Headings
- Signal Transduction
- Protein Structure, Secondary
- Peptides
- Molecular Sequence Data
- Models, Molecular
- General Science & Technology
- Crystallography, X-Ray
- Computer Graphics
- Calmodulin
- Calcium-Calmodulin-Dependent Protein Kinases
Citation
APA
Chicago
ICMJE
MLA
NLM
Meador, W. E., Means, A. R., & Quiocho, F. A. (1993). Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures. Science, 262(5140), 1718–1721. https://doi.org/10.1126/science.8259515
Meador, W. E., A. R. Means, and F. A. Quiocho. “Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.” Science 262, no. 5140 (December 10, 1993): 1718–21. https://doi.org/10.1126/science.8259515.
Meador WE, Means AR, Quiocho FA. Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures. Science. 1993 Dec 10;262(5140):1718–21.
Meador, W. E., et al. “Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.” Science, vol. 262, no. 5140, Dec. 1993, pp. 1718–21. Pubmed, doi:10.1126/science.8259515.
Meador WE, Means AR, Quiocho FA. Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures. Science. 1993 Dec 10;262(5140):1718–1721.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
December 10, 1993
Volume
262
Issue
5140
Start / End Page
1718 / 1721
Location
United States
Related Subject Headings
- Signal Transduction
- Protein Structure, Secondary
- Peptides
- Molecular Sequence Data
- Models, Molecular
- General Science & Technology
- Crystallography, X-Ray
- Computer Graphics
- Calmodulin
- Calcium-Calmodulin-Dependent Protein Kinases