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Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.

Publication ,  Journal Article
Meador, WE; Means, AR; Quiocho, FA
Published in: Science
December 10, 1993

Calmodulin is the primary calcium-dependent signal transducer and regulator of a wide variety of essential cellular functions. The structure of calcium-calmodulin bound to the peptide corresponding to the calmodulin-binding domain of brain calmodulin-dependent protein kinase II alpha was determined to 2 angstrom resolution. A comparison to two other calcium-calmodulin structures reveals how the central helix unwinds in order to position the two domains optimally in the recognition of different target enzymes and clarifies the role of calcium in maintaining recognition-competent domain structures.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

December 10, 1993

Volume

262

Issue

5140

Start / End Page

1718 / 1721

Location

United States

Related Subject Headings

  • Signal Transduction
  • Protein Structure, Secondary
  • Peptides
  • Molecular Sequence Data
  • Models, Molecular
  • General Science & Technology
  • Crystallography, X-Ray
  • Computer Graphics
  • Calmodulin
  • Calcium-Calmodulin-Dependent Protein Kinases
 

Citation

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Meador, W. E., Means, A. R., & Quiocho, F. A. (1993). Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures. Science, 262(5140), 1718–1721. https://doi.org/10.1126/science.8259515
Meador, W. E., A. R. Means, and F. A. Quiocho. “Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.Science 262, no. 5140 (December 10, 1993): 1718–21. https://doi.org/10.1126/science.8259515.
Meador WE, Means AR, Quiocho FA. Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures. Science. 1993 Dec 10;262(5140):1718–21.
Meador, W. E., et al. “Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.Science, vol. 262, no. 5140, Dec. 1993, pp. 1718–21. Pubmed, doi:10.1126/science.8259515.
Meador WE, Means AR, Quiocho FA. Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures. Science. 1993 Dec 10;262(5140):1718–1721.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

December 10, 1993

Volume

262

Issue

5140

Start / End Page

1718 / 1721

Location

United States

Related Subject Headings

  • Signal Transduction
  • Protein Structure, Secondary
  • Peptides
  • Molecular Sequence Data
  • Models, Molecular
  • General Science & Technology
  • Crystallography, X-Ray
  • Computer Graphics
  • Calmodulin
  • Calcium-Calmodulin-Dependent Protein Kinases