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Estrogen-induced changes in translation, and specific messenger RNA levels during oviduct differentiation.

Publication ,  Journal Article
Comstock, JP; Rosenfeld, GC; O'Malley, BW; Means, AR
Published in: Proc Natl Acad Sci U S A
September 1972

Estrogen-induced morphologic differentiation of chick oviduct is accompanied by increases in the total endogenous mRNA activity of oviduct polysomes. Concomitant increases are also noted in ribosome translational capacity and activity of peptide chain initiation factors. Once the differentiation process nears completion (about 7 days of estrogen administration), total ribosomebound mRNA activity decreases, but the translational machinery remains very active. In addition, estrogen induces the accumulation of ovalbumin mRNA before ovalbumin is demonstrable in the oviduct. The data suggest that the rate-limiting event in the hormonal induction of cell-specific proteins, such as ovalbumin, is the synthesis and intracellular accumulation of specific mRNA for such proteins.

Duke Scholars

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

September 1972

Volume

69

Issue

9

Start / End Page

2377 / 2380

Location

United States

Related Subject Headings

  • Valine
  • Uracil Nucleotides
  • Ribosomes
  • Reticulocytes
  • Rabbits
  • RNA, Transfer
  • RNA, Messenger
  • Protein Biosynthesis
  • Polynucleotides
  • Phenylalanine
 

Citation

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Comstock, J. P., Rosenfeld, G. C., O’Malley, B. W., & Means, A. R. (1972). Estrogen-induced changes in translation, and specific messenger RNA levels during oviduct differentiation. Proc Natl Acad Sci U S A, 69(9), 2377–2380. https://doi.org/10.1073/pnas.69.9.2377
Comstock, J. P., G. C. Rosenfeld, B. W. O’Malley, and A. R. Means. “Estrogen-induced changes in translation, and specific messenger RNA levels during oviduct differentiation.Proc Natl Acad Sci U S A 69, no. 9 (September 1972): 2377–80. https://doi.org/10.1073/pnas.69.9.2377.
Comstock JP, Rosenfeld GC, O’Malley BW, Means AR. Estrogen-induced changes in translation, and specific messenger RNA levels during oviduct differentiation. Proc Natl Acad Sci U S A. 1972 Sep;69(9):2377–80.
Comstock, J. P., et al. “Estrogen-induced changes in translation, and specific messenger RNA levels during oviduct differentiation.Proc Natl Acad Sci U S A, vol. 69, no. 9, Sept. 1972, pp. 2377–80. Pubmed, doi:10.1073/pnas.69.9.2377.
Comstock JP, Rosenfeld GC, O’Malley BW, Means AR. Estrogen-induced changes in translation, and specific messenger RNA levels during oviduct differentiation. Proc Natl Acad Sci U S A. 1972 Sep;69(9):2377–2380.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

September 1972

Volume

69

Issue

9

Start / End Page

2377 / 2380

Location

United States

Related Subject Headings

  • Valine
  • Uracil Nucleotides
  • Ribosomes
  • Reticulocytes
  • Rabbits
  • RNA, Transfer
  • RNA, Messenger
  • Protein Biosynthesis
  • Polynucleotides
  • Phenylalanine