Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair.
Publication
, Journal Article
Chafouleas, JG; Bolton, WE; Means, AR
Published in: Science (New York, N.Y.)
June 1984
Treatment of exponentially growing Chinese hamster ovary cells with bleomycin causes a dose-dependent decrease in cell survival due to DNA damage. This lethal effect can be potentiated by the addition of a nonlethal dose of the anticalmodulin drug N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide ( W13 ) but not its inactive analog N-(4-aminobutyl)-2-naphthalenesulfonamide ( W12 ). By preventing the repair of damaged DNA, W13 also inhibits recovery from potentially lethal damage induced by bleomycin. These data suggest a role for calmodulin in the DNA repair pathway.
Duke Scholars
Published In
Science (New York, N.Y.)
DOI
EISSN
1095-9203
ISSN
0036-8075
Publication Date
June 1984
Volume
224
Issue
4655
Start / End Page
1346 / 1348
Related Subject Headings
- Sulfonamides
- General Science & Technology
- Drug Synergism
- Dose-Response Relationship, Drug
- DNA Repair
- Cricetulus
- Cricetinae
- Cell Survival
- Cell Line
- Cell Division
Citation
APA
Chicago
ICMJE
MLA
NLM
Chafouleas, J. G., Bolton, W. E., & Means, A. R. (1984). Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair. Science (New York, N.Y.), 224(4655), 1346–1348. https://doi.org/10.1126/science.6203171
Chafouleas, J. G., W. E. Bolton, and A. R. Means. “Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair.” Science (New York, N.Y.) 224, no. 4655 (June 1984): 1346–48. https://doi.org/10.1126/science.6203171.
Chafouleas JG, Bolton WE, Means AR. Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair. Science (New York, NY). 1984 Jun;224(4655):1346–8.
Chafouleas, J. G., et al. “Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair.” Science (New York, N.Y.), vol. 224, no. 4655, June 1984, pp. 1346–48. Epmc, doi:10.1126/science.6203171.
Chafouleas JG, Bolton WE, Means AR. Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair. Science (New York, NY). 1984 Jun;224(4655):1346–1348.
Published In
Science (New York, N.Y.)
DOI
EISSN
1095-9203
ISSN
0036-8075
Publication Date
June 1984
Volume
224
Issue
4655
Start / End Page
1346 / 1348
Related Subject Headings
- Sulfonamides
- General Science & Technology
- Drug Synergism
- Dose-Response Relationship, Drug
- DNA Repair
- Cricetulus
- Cricetinae
- Cell Survival
- Cell Line
- Cell Division