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Ca(2+)/calmodulin-dependent kinase is essential for both growth and nuclear division in Aspergillus nidulans.

Publication ,  Journal Article
Dayton, JS; Means, AR
Published in: Mol Biol Cell
October 1996

The calmodulin gene has been shown to be essential for cell cycle progression in a number of eukaryotic organisms. In vertebrates and Aspergillus nidulans the calmodulin dependence also requires calcium. We demonstrate that the unique gene encoding a multifunctional calcium/calmodulin-dependent protein kinase (CaMK) is also essential in A. nidulans. This enzyme is required both for the nuclear division cycle and for hyphal growth, because spores containing the disrupted gene arrest with a single nucleus and fail to extend a germ tube. A strain conditional for the expression of CaMK was created. When grown under conditions that resulted in a 90% decrease in the enzyme, both nuclear division and growth were markedly slowed. The CaMK seems to be important for progression from G2 to mitosis.

Duke Scholars

Published In

Mol Biol Cell

DOI

ISSN

1059-1524

Publication Date

October 1996

Volume

7

Issue

10

Start / End Page

1511 / 1519

Location

United States

Related Subject Headings

  • Genes, Fungal
  • G2 Phase
  • Fungal Proteins
  • Developmental Biology
  • Cell Nucleus
  • Cell Division
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Calcium
  • Aspergillus nidulans
  • 11 Medical and Health Sciences
 

Citation

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Dayton, J. S., & Means, A. R. (1996). Ca(2+)/calmodulin-dependent kinase is essential for both growth and nuclear division in Aspergillus nidulans. Mol Biol Cell, 7(10), 1511–1519. https://doi.org/10.1091/mbc.7.10.1511
Dayton, J. S., and A. R. Means. “Ca(2+)/calmodulin-dependent kinase is essential for both growth and nuclear division in Aspergillus nidulans.Mol Biol Cell 7, no. 10 (October 1996): 1511–19. https://doi.org/10.1091/mbc.7.10.1511.
Dayton, J. S., and A. R. Means. “Ca(2+)/calmodulin-dependent kinase is essential for both growth and nuclear division in Aspergillus nidulans.Mol Biol Cell, vol. 7, no. 10, Oct. 1996, pp. 1511–19. Pubmed, doi:10.1091/mbc.7.10.1511.

Published In

Mol Biol Cell

DOI

ISSN

1059-1524

Publication Date

October 1996

Volume

7

Issue

10

Start / End Page

1511 / 1519

Location

United States

Related Subject Headings

  • Genes, Fungal
  • G2 Phase
  • Fungal Proteins
  • Developmental Biology
  • Cell Nucleus
  • Cell Division
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Calcium
  • Aspergillus nidulans
  • 11 Medical and Health Sciences