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Mutations of the E-cadherin gene in human gynecologic cancers.

Publication ,  Journal Article
Risinger, JI; Berchuck, A; Kohler, MF; Boyd, J
Published in: Nat Genet
May 1994

Expression of the E-cadherin cell adhesion molecule is reduced in several types of human carcinomas, and the protein serves as an invasion suppressor in vitro. To determine if mutations of the E-cadherin gene (on chromosome 16q22) contribute to epithelial tumorigenesis, 135 carcinomas of the endometrium and ovary were examined for alterations in the E-cadherin coding region. Four mutations were identified: one somatic nonsense and one somatic missense mutation, both with retention of the wild-type alleles, and two missense mutations with somatic loss of heterozygosity in the tumour tissue. These data support the classification of E-cadherin as a human tumour suppressor gene.

Duke Scholars

Published In

Nat Genet

DOI

ISSN

1061-4036

Publication Date

May 1994

Volume

7

Issue

1

Start / End Page

98 / 102

Location

United States

Related Subject Headings

  • Polymorphism, Genetic
  • Polymerase Chain Reaction
  • Point Mutation
  • Ovarian Neoplasms
  • Neoplasm Proteins
  • Molecular Sequence Data
  • Humans
  • Gene Expression Regulation, Neoplastic
  • Gene Deletion
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Risinger, J. I., Berchuck, A., Kohler, M. F., & Boyd, J. (1994). Mutations of the E-cadherin gene in human gynecologic cancers. Nat Genet, 7(1), 98–102. https://doi.org/10.1038/ng0594-98
Risinger, J. I., A. Berchuck, M. F. Kohler, and J. Boyd. “Mutations of the E-cadherin gene in human gynecologic cancers.Nat Genet 7, no. 1 (May 1994): 98–102. https://doi.org/10.1038/ng0594-98.
Risinger JI, Berchuck A, Kohler MF, Boyd J. Mutations of the E-cadherin gene in human gynecologic cancers. Nat Genet. 1994 May;7(1):98–102.
Risinger, J. I., et al. “Mutations of the E-cadherin gene in human gynecologic cancers.Nat Genet, vol. 7, no. 1, May 1994, pp. 98–102. Pubmed, doi:10.1038/ng0594-98.
Risinger JI, Berchuck A, Kohler MF, Boyd J. Mutations of the E-cadherin gene in human gynecologic cancers. Nat Genet. 1994 May;7(1):98–102.

Published In

Nat Genet

DOI

ISSN

1061-4036

Publication Date

May 1994

Volume

7

Issue

1

Start / End Page

98 / 102

Location

United States

Related Subject Headings

  • Polymorphism, Genetic
  • Polymerase Chain Reaction
  • Point Mutation
  • Ovarian Neoplasms
  • Neoplasm Proteins
  • Molecular Sequence Data
  • Humans
  • Gene Expression Regulation, Neoplastic
  • Gene Deletion
  • Female