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The p53 tumor suppressor gene frequently is altered in gynecologic cancers.

Publication ,  Journal Article
Berchuck, A; Kohler, MF; Marks, JR; Wiseman, R; Boyd, J; Bast, RC
Published in: Am J Obstet Gynecol
January 1994

Mutation of the p53 tumor suppressor gene, often accompanied by overexpression of mutant p53 protein, is the most frequent molecular genetic event described thus far in human cancers. In adenocarcinomas of the ovary and endometrium, p53 overexpression is seen in approximately 10% to 15% of early and 40% to 50% of advanced cancers. Similar to many other types of human cancers, ovarian and endometrial cancers that overexpress p53 protein contain mutations in conserved regions of the p53 gene. These mutations are predominantly transitions, which suggests that they arise spontaneously rather than being caused by carcinogen exposure. Alteration of the p53 gene does not appear to be a feature of endometrial hyperplasias or benign or borderline ovarian tumors. Although mutation and overexpression of p53 rarely occur in cancers of the cervix, vulva, and vagina, it has been shown that human papillomavirus E6 oncoproteins bind to and inactivate p53 protein. Studies of the p53 gene have begun to provide insight into the molecular pathogenesis of gynecologic cancers.

Duke Scholars

Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

January 1994

Volume

170

Issue

1 Pt 1

Start / End Page

246 / 252

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Sarcoma
  • Obstetrics & Reproductive Medicine
  • Neoplasms, Germ Cell and Embryonal
  • Mutation
  • Humans
  • Genital Neoplasms, Female
  • Genes, p53
  • Gene Expression Regulation, Neoplastic
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Berchuck, A., Kohler, M. F., Marks, J. R., Wiseman, R., Boyd, J., & Bast, R. C. (1994). The p53 tumor suppressor gene frequently is altered in gynecologic cancers. Am J Obstet Gynecol, 170(1 Pt 1), 246–252. https://doi.org/10.1016/s0002-9378(94)70414-7
Berchuck, A., M. F. Kohler, J. R. Marks, R. Wiseman, J. Boyd, and R. C. Bast. “The p53 tumor suppressor gene frequently is altered in gynecologic cancers.Am J Obstet Gynecol 170, no. 1 Pt 1 (January 1994): 246–52. https://doi.org/10.1016/s0002-9378(94)70414-7.
Berchuck A, Kohler MF, Marks JR, Wiseman R, Boyd J, Bast RC. The p53 tumor suppressor gene frequently is altered in gynecologic cancers. Am J Obstet Gynecol. 1994 Jan;170(1 Pt 1):246–52.
Berchuck, A., et al. “The p53 tumor suppressor gene frequently is altered in gynecologic cancers.Am J Obstet Gynecol, vol. 170, no. 1 Pt 1, Jan. 1994, pp. 246–52. Pubmed, doi:10.1016/s0002-9378(94)70414-7.
Berchuck A, Kohler MF, Marks JR, Wiseman R, Boyd J, Bast RC. The p53 tumor suppressor gene frequently is altered in gynecologic cancers. Am J Obstet Gynecol. 1994 Jan;170(1 Pt 1):246–252.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

January 1994

Volume

170

Issue

1 Pt 1

Start / End Page

246 / 252

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Sarcoma
  • Obstetrics & Reproductive Medicine
  • Neoplasms, Germ Cell and Embryonal
  • Mutation
  • Humans
  • Genital Neoplasms, Female
  • Genes, p53
  • Gene Expression Regulation, Neoplastic
  • Female