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Influence of panel-reactive antibodies on posttransplant outcomes in lung transplant recipients.

Publication ,  Journal Article
Lau, CL; Palmer, SM; Posther, KE; Howell, DN; Reinsmoen, NL; Massey, HT; Tapson, VF; Jaggers, JJ; D'Amico, TA; Davis, RD
Published in: Ann Thorac Surg
May 2000

BACKGROUND: Panel-reactive antibody (PRA) is used to estimate the degree of humoral sensitization in the recipient before transplantation. Although pretransplant sensitization is associated with increased complications in other solid organ transplant recipients, less is known about the outcome of sensitized lung transplant recipients. Therefore, we sought to determine the impact of elevated pretransplant PRA on clinical outcomes after lung transplantation. METHODS: The records of the first 200 lung transplant operations performed at Duke University Medical Center were reviewed. The outcomes of sensitized patients, PRA greater than 10% before transplantation (n = 18), were compared with the outcomes of nonsensitized patients. RESULTS: Sensitized patients experienced a significantly greater number of median ventilator days posttransplant (9 +/- 8) as compared with nonsensitized recipients (1 +/- 11; p = 0.0008). There were no significant differences between the number of episodes of acute rejection; however, there was a significantly increased incidence of bronchiolitis obliterans syndrome occurring in untreated sensitized recipients (56%) versus nonsensitized (23%; p = 0.044). In addition, there was a trend towards decreased survival in the sensitized recipients, with a 2-year survival of 58% in sensitized recipients as compared with 73% in the nonsensitized patients (p = 0.31). CONCLUSIONS: Sensitized lung transplant recipients experience more acute and chronic complications after transplantation. These patients probably warrant alternative management strategies.

Duke Scholars

Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

May 2000

Volume

69

Issue

5

Start / End Page

1520 / 1524

Location

Netherlands

Related Subject Headings

  • Ventilators, Mechanical
  • Treatment Outcome
  • Survival Rate
  • Retrospective Studies
  • Respiratory System
  • Middle Aged
  • Male
  • Lung Transplantation
  • Length of Stay
  • Immunization
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lau, C. L., Palmer, S. M., Posther, K. E., Howell, D. N., Reinsmoen, N. L., Massey, H. T., … Davis, R. D. (2000). Influence of panel-reactive antibodies on posttransplant outcomes in lung transplant recipients. Ann Thorac Surg, 69(5), 1520–1524. https://doi.org/10.1016/s0003-4975(00)01224-8
Lau, C. L., S. M. Palmer, K. E. Posther, D. N. Howell, N. L. Reinsmoen, H. T. Massey, V. F. Tapson, J. J. Jaggers, T. A. D’Amico, and R. D. Davis. “Influence of panel-reactive antibodies on posttransplant outcomes in lung transplant recipients.Ann Thorac Surg 69, no. 5 (May 2000): 1520–24. https://doi.org/10.1016/s0003-4975(00)01224-8.
Lau CL, Palmer SM, Posther KE, Howell DN, Reinsmoen NL, Massey HT, et al. Influence of panel-reactive antibodies on posttransplant outcomes in lung transplant recipients. Ann Thorac Surg. 2000 May;69(5):1520–4.
Lau, C. L., et al. “Influence of panel-reactive antibodies on posttransplant outcomes in lung transplant recipients.Ann Thorac Surg, vol. 69, no. 5, May 2000, pp. 1520–24. Pubmed, doi:10.1016/s0003-4975(00)01224-8.
Lau CL, Palmer SM, Posther KE, Howell DN, Reinsmoen NL, Massey HT, Tapson VF, Jaggers JJ, D’Amico TA, Davis RD. Influence of panel-reactive antibodies on posttransplant outcomes in lung transplant recipients. Ann Thorac Surg. 2000 May;69(5):1520–1524.
Journal cover image

Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

May 2000

Volume

69

Issue

5

Start / End Page

1520 / 1524

Location

Netherlands

Related Subject Headings

  • Ventilators, Mechanical
  • Treatment Outcome
  • Survival Rate
  • Retrospective Studies
  • Respiratory System
  • Middle Aged
  • Male
  • Lung Transplantation
  • Length of Stay
  • Immunization