Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

The role of innate immunity in acute allograft rejection after lung transplantation.

Publication ,  Journal Article
Palmer, SM; Burch, LH; Davis, RD; Herczyk, WF; Howell, DN; Reinsmoen, NL; Schwartz, DA
Published in: Am J Respir Crit Care Med
September 15, 2003

Although innate immunity is crucial to pulmonary host defense and can initiate immune and inflammatory responses independent of adaptive immunity, it remains unstudied in the context of transplant rejection. To investigate the role of innate immunity in the development of allograft rejection, we assessed the impact of two functional polymorphisms in the toll-like receptor 4 (TLR4) associated with endotoxin hyporesponsiveness on the development of acute rejection after human lung transplantation. Patients and donors were screened for the TLR4 Asp299Gly and Thr399Ile polymorphisms by polymerase chain reaction using sequence-specific primers. The rate of acute rejection at 6 months was significantly reduced in recipients, but not in donors, with the Asp299Gly or Thr399Ile alleles as compared with wild type (29 vs. 56%, respectively, p = 0.05). This association was confirmed in Cox proportional hazards and multivariate logistic regression models. Our results suggest activation of innate immunity in lung transplant recipients through TLR4 contributes to the development acute rejection after lung transplantation. Therapies directed at inhibition of innate immune responses mediated by TLR4 may represent a novel and effective means to prevent acute rejection after lung transplantation.

Duke Scholars

Published In

Am J Respir Crit Care Med

DOI

ISSN

1073-449X

Publication Date

September 15, 2003

Volume

168

Issue

6

Start / End Page

628 / 632

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Immunology
  • Toll-Like Receptors
  • Toll-Like Receptor 4
  • Risk Assessment
  • Retrospective Studies
  • Respiratory System
  • Receptors, Cell Surface
  • Proportional Hazards Models
  • Polymorphism, Genetic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Palmer, S. M., Burch, L. H., Davis, R. D., Herczyk, W. F., Howell, D. N., Reinsmoen, N. L., & Schwartz, D. A. (2003). The role of innate immunity in acute allograft rejection after lung transplantation. Am J Respir Crit Care Med, 168(6), 628–632. https://doi.org/10.1164/rccm.200303-447OC
Palmer, Scott M., Lauranell H. Burch, R Duane Davis, Walter F. Herczyk, David N. Howell, Nancy L. Reinsmoen, and David A. Schwartz. “The role of innate immunity in acute allograft rejection after lung transplantation.Am J Respir Crit Care Med 168, no. 6 (September 15, 2003): 628–32. https://doi.org/10.1164/rccm.200303-447OC.
Palmer SM, Burch LH, Davis RD, Herczyk WF, Howell DN, Reinsmoen NL, et al. The role of innate immunity in acute allograft rejection after lung transplantation. Am J Respir Crit Care Med. 2003 Sep 15;168(6):628–32.
Palmer, Scott M., et al. “The role of innate immunity in acute allograft rejection after lung transplantation.Am J Respir Crit Care Med, vol. 168, no. 6, Sept. 2003, pp. 628–32. Pubmed, doi:10.1164/rccm.200303-447OC.
Palmer SM, Burch LH, Davis RD, Herczyk WF, Howell DN, Reinsmoen NL, Schwartz DA. The role of innate immunity in acute allograft rejection after lung transplantation. Am J Respir Crit Care Med. 2003 Sep 15;168(6):628–632.

Published In

Am J Respir Crit Care Med

DOI

ISSN

1073-449X

Publication Date

September 15, 2003

Volume

168

Issue

6

Start / End Page

628 / 632

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Immunology
  • Toll-Like Receptors
  • Toll-Like Receptor 4
  • Risk Assessment
  • Retrospective Studies
  • Respiratory System
  • Receptors, Cell Surface
  • Proportional Hazards Models
  • Polymorphism, Genetic