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Leptin regulates proinflammatory immune responses.

Publication ,  Journal Article
Loffreda, S; Yang, SQ; Lin, HZ; Karp, CL; Brengman, ML; Wang, DJ; Klein, AS; Bulkley, GB; Bao, C; Noble, PW; Lane, MD; Diehl, AM
Published in: FASEB J
January 1998

Obesity is associated with an increased incidence of infection, diabetes, and cardiovascular disease, which together account for most obesity-related morbidity and mortality. Decreased expression of leptin or of functional leptin receptors results in hyperphagia, decreased energy expenditure, and obesity. It is unclear, however, whether defective leptin-dependent signal transduction directly promotes any of the conditions that frequently complicate obesity. Abnormalities in tumor necrosis factor alpha expression have been noted in each of the above comorbid conditions, so leptin deficiency could promote these complications if leptin had immunoregulatory activity. Studies of rodents with genetic abnormalities in leptin or leptin receptors revealed obesity-related deficits in macrophage phagocytosis and the expression of proinflammatory cytokines both in vivo and in vitro. Exogenous leptin up-regulated both phagocytosis and the production of proinflammatory cytokines. These results identify an important and novel function for leptin: up-regulation of inflammatory immune responses, which may provide a common pathogenetic mechanism that contributes to several of the major complications of obesity.

Duke Scholars

Published In

FASEB J

ISSN

0892-6638

Publication Date

January 1998

Volume

12

Issue

1

Start / End Page

57 / 65

Location

United States

Related Subject Headings

  • Recombinant Proteins
  • Receptors, Leptin
  • Receptors, Cell Surface
  • Proteins
  • Phagocytosis
  • Mice, Obese
  • Mice
  • Macrophages
  • Lipopolysaccharides
  • Leptin
 

Citation

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Loffreda, S., Yang, S. Q., Lin, H. Z., Karp, C. L., Brengman, M. L., Wang, D. J., … Diehl, A. M. (1998). Leptin regulates proinflammatory immune responses. FASEB J, 12(1), 57–65.
Loffreda, S., S. Q. Yang, H. Z. Lin, C. L. Karp, M. L. Brengman, D. J. Wang, A. S. Klein, et al. “Leptin regulates proinflammatory immune responses.FASEB J 12, no. 1 (January 1998): 57–65.
Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, et al. Leptin regulates proinflammatory immune responses. FASEB J. 1998 Jan;12(1):57–65.
Loffreda, S., et al. “Leptin regulates proinflammatory immune responses.FASEB J, vol. 12, no. 1, Jan. 1998, pp. 57–65.
Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, Klein AS, Bulkley GB, Bao C, Noble PW, Lane MD, Diehl AM. Leptin regulates proinflammatory immune responses. FASEB J. 1998 Jan;12(1):57–65.

Published In

FASEB J

ISSN

0892-6638

Publication Date

January 1998

Volume

12

Issue

1

Start / End Page

57 / 65

Location

United States

Related Subject Headings

  • Recombinant Proteins
  • Receptors, Leptin
  • Receptors, Cell Surface
  • Proteins
  • Phagocytosis
  • Mice, Obese
  • Mice
  • Macrophages
  • Lipopolysaccharides
  • Leptin