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Combination treatment of bullous pemphigoid with anti-CD20 and anti-CD25 antibodies in a patient with chronic graft-versus-host disease.

Publication ,  Journal Article
Szabolcs, P; Reese, M; Yancey, KB; Hall, RP; Kurtzberg, J
Published in: Bone Marrow Transplant
September 2002

In this case report we describe a novel treatment with two chimeric monoclonal antibodies (MoAb) targeting the autoimmune B cell clone responsible for bullous pemphigoid (BP) as a manifestation of steroid refractory chronic graft-versus-host disease (GVHD) that developed after unrelated cord blood transplantation. Monitoring the BP-specific circulating antibodies and CD25-expressing activated T lymphocyte subset led us to combine anti-CD20 (Rituximab) mediated B cell ablation with anti-CD25 (Daclizumab) therapy to block CD4(+) T cell help. Complete clinical and serologic response was achieved within 4 weeks of initiation of therapy allowing global immunosuppression to be dramatically reduced.

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Published In

Bone Marrow Transplant

DOI

ISSN

0268-3369

Publication Date

September 2002

Volume

30

Issue

5

Start / End Page

327 / 329

Location

England

Related Subject Headings

  • Treatment Outcome
  • Receptors, Interleukin-2
  • Pemphigoid, Bullous
  • Male
  • Immunology
  • Humans
  • Graft vs Host Disease
  • Drug Therapy, Combination
  • Cord Blood Stem Cell Transplantation
  • Chronic Disease
 

Citation

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Szabolcs, P., Reese, M., Yancey, K. B., Hall, R. P., & Kurtzberg, J. (2002). Combination treatment of bullous pemphigoid with anti-CD20 and anti-CD25 antibodies in a patient with chronic graft-versus-host disease. Bone Marrow Transplant, 30(5), 327–329. https://doi.org/10.1038/sj.bmt.1703654
Szabolcs, P., M. Reese, K. B. Yancey, R. P. Hall, and J. Kurtzberg. “Combination treatment of bullous pemphigoid with anti-CD20 and anti-CD25 antibodies in a patient with chronic graft-versus-host disease.Bone Marrow Transplant 30, no. 5 (September 2002): 327–29. https://doi.org/10.1038/sj.bmt.1703654.
Szabolcs P, Reese M, Yancey KB, Hall RP, Kurtzberg J. Combination treatment of bullous pemphigoid with anti-CD20 and anti-CD25 antibodies in a patient with chronic graft-versus-host disease. Bone Marrow Transplant. 2002 Sep;30(5):327–9.
Szabolcs, P., et al. “Combination treatment of bullous pemphigoid with anti-CD20 and anti-CD25 antibodies in a patient with chronic graft-versus-host disease.Bone Marrow Transplant, vol. 30, no. 5, Sept. 2002, pp. 327–29. Pubmed, doi:10.1038/sj.bmt.1703654.
Szabolcs P, Reese M, Yancey KB, Hall RP, Kurtzberg J. Combination treatment of bullous pemphigoid with anti-CD20 and anti-CD25 antibodies in a patient with chronic graft-versus-host disease. Bone Marrow Transplant. 2002 Sep;30(5):327–329.

Published In

Bone Marrow Transplant

DOI

ISSN

0268-3369

Publication Date

September 2002

Volume

30

Issue

5

Start / End Page

327 / 329

Location

England

Related Subject Headings

  • Treatment Outcome
  • Receptors, Interleukin-2
  • Pemphigoid, Bullous
  • Male
  • Immunology
  • Humans
  • Graft vs Host Disease
  • Drug Therapy, Combination
  • Cord Blood Stem Cell Transplantation
  • Chronic Disease