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Infectious complications of treatment with biologic agents.

Publication ,  Journal Article
Hamilton, CD
Published in: Current opinion in rheumatology
July 2004

There are three tumor necrosis factor-alpha inhibitors on the US and European markets today, and uncommon but devastating infectious complications accompany their use. This review describes the most important pathogen-specific infections and their relative frequency. Recent literature is summarized that has helped elucidate the pathophysiologic basis for their occurrence. Finally, evolving sets of recommendations for prevention, diagnosis, and treatment of infectious complications of their use are explored.Tuberculosis has continued to be the most common pathogen reported in association with infliximab, and less so with etanercept and adalimumab. Determining treated population case rates depends on having an accurate denominator and reflects the local population's latent infection rate. The same is true for histoplasmosis. Other pathogens requiring intact cellular immunity for control of latent infection have also been reported. Specific recommendations for preventive therapy are being made, but prospective clinical trials are needed to assess the risk-benefit of any particular approach.Microorganisms responsible for the infectious complications associated with anticytokine therapy are generally intracellular pathogens or pathogens that commonly exist in a chronic, latent state and are normally held in check by cell-mediated immunity. Diagnosis requires a high index of suspicion and prompt acquisition of appropriate tissue for microscopic examination and microbiologic culture. Prompt empiric therapy that focuses on the most likely infections is necessary to prevent mortality.

Duke Scholars

Published In

Current opinion in rheumatology

DOI

EISSN

1531-6963

ISSN

1040-8711

Publication Date

July 2004

Volume

16

Issue

4

Start / End Page

393 / 398

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Tuberculosis
  • Infections
  • Humans
  • Biological Therapy
  • Arthritis & Rheumatology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hamilton, C. D. (2004). Infectious complications of treatment with biologic agents. Current Opinion in Rheumatology, 16(4), 393–398. https://doi.org/10.1097/01.bor.0000127594.92432.7c
Hamilton, Carol Dukes. “Infectious complications of treatment with biologic agents.Current Opinion in Rheumatology 16, no. 4 (July 2004): 393–98. https://doi.org/10.1097/01.bor.0000127594.92432.7c.
Hamilton CD. Infectious complications of treatment with biologic agents. Current opinion in rheumatology. 2004 Jul;16(4):393–8.
Hamilton, Carol Dukes. “Infectious complications of treatment with biologic agents.Current Opinion in Rheumatology, vol. 16, no. 4, July 2004, pp. 393–98. Epmc, doi:10.1097/01.bor.0000127594.92432.7c.
Hamilton CD. Infectious complications of treatment with biologic agents. Current opinion in rheumatology. 2004 Jul;16(4):393–398.

Published In

Current opinion in rheumatology

DOI

EISSN

1531-6963

ISSN

1040-8711

Publication Date

July 2004

Volume

16

Issue

4

Start / End Page

393 / 398

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Tuberculosis
  • Infections
  • Humans
  • Biological Therapy
  • Arthritis & Rheumatology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences