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HLA-DR15 haplotype and multiple sclerosis: a HuGE review.

Publication ,  Journal Article
Schmidt, H; Williamson, D; Ashley-Koch, A
Published in: Am J Epidemiol
May 15, 2007

An association between multiple sclerosis (MS) and the human leukocyte antigen (HLA) complex, a dense cluster of genes on the short arm of chromosome 6, was first noted over 30 years ago. In Caucasian populations of Northern European descent, the DR15 haplotype (DRB1*1501-DQA1*0102-DQB1*0602) has been hypothesized to be the primary HLA genetic susceptibility factor for MS. However, studies of other populations have produced varying results. Thus, the authors reviewed the literature for articles on the association between the DR15 haplotype and MS. They identified 72 papers meeting the inclusion criteria: human genetic studies written in English that were published between 1993 and 2004 and that reported allele frequencies for HLA-DRB1*1501, HLA-DQA1*0102, or HLA-DQB1*0602 or the frequency of the DRB1*1501-DQA1*0102-DQB1*0602 haplotype. Most of the studies identified used a case-control design (n = 60), while the remainder used a family-based design (n = 22). In most of these papers, investigators reported a higher frequency of the DR15 haplotype and/or its component alleles among MS cases than among controls. However, the authors' confidence in these results is tempered by factors related to study design that may have biased the outcomes.

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Published In

Am J Epidemiol

DOI

ISSN

0002-9262

Publication Date

May 15, 2007

Volume

165

Issue

10

Start / End Page

1097 / 1109

Location

United States

Related Subject Headings

  • Multiple Sclerosis
  • Multigene Family
  • Humans
  • Haplotypes
  • HLA-D Antigens
  • Epidemiology
  • Alleles
  • 4202 Epidemiology
  • 11 Medical and Health Sciences
  • 01 Mathematical Sciences
 

Citation

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Schmidt, H., Williamson, D., & Ashley-Koch, A. (2007). HLA-DR15 haplotype and multiple sclerosis: a HuGE review. Am J Epidemiol, 165(10), 1097–1109. https://doi.org/10.1093/aje/kwk118
Schmidt, Hollie, Dhelia Williamson, and Allison Ashley-Koch. “HLA-DR15 haplotype and multiple sclerosis: a HuGE review.Am J Epidemiol 165, no. 10 (May 15, 2007): 1097–1109. https://doi.org/10.1093/aje/kwk118.
Schmidt H, Williamson D, Ashley-Koch A. HLA-DR15 haplotype and multiple sclerosis: a HuGE review. Am J Epidemiol. 2007 May 15;165(10):1097–109.
Schmidt, Hollie, et al. “HLA-DR15 haplotype and multiple sclerosis: a HuGE review.Am J Epidemiol, vol. 165, no. 10, May 2007, pp. 1097–109. Pubmed, doi:10.1093/aje/kwk118.
Schmidt H, Williamson D, Ashley-Koch A. HLA-DR15 haplotype and multiple sclerosis: a HuGE review. Am J Epidemiol. 2007 May 15;165(10):1097–1109.
Journal cover image

Published In

Am J Epidemiol

DOI

ISSN

0002-9262

Publication Date

May 15, 2007

Volume

165

Issue

10

Start / End Page

1097 / 1109

Location

United States

Related Subject Headings

  • Multiple Sclerosis
  • Multigene Family
  • Humans
  • Haplotypes
  • HLA-D Antigens
  • Epidemiology
  • Alleles
  • 4202 Epidemiology
  • 11 Medical and Health Sciences
  • 01 Mathematical Sciences