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Treatment of intracranial alphavirus infections in mice by a combination of specific antibodies and an interferon inducer.

Publication ,  Journal Article
Coppenhaver, DH; Singh, IP; Sarzotti, M; Levy, HB; Baron, S
Published in: Am J Trop Med Hyg
January 1995

Finding an effective treatment for viral infections that cause encephalitis remains an important problem. A model of human alphavirus infections, Semliki Forest virus, causes lethal encephalitis in weanling mice. Mice are viremic within 24 hr of an intraperitoneal challenge with the equivalent of three 75% lethal doses of Semliki Forest virus. Virus reaches the brain by 48 hr, and mortality results in all mice in 5-7 days. Introduction of virus intracranially accelerates the course of the infection. Neither anti-Semliki Forest virus hyperimmune serum nor the potent interferon inducer poly I:CLC given intraperitoneally are protective when used therapeutically after an intracranial virus infection, but a combination of 1,000 U hyperimmune serum and 80 micrograms/mouse of poly I:CLC results in a 50% survival rate. This combination treatment of intracranial Semliki Forest virus infection eliminates detectable viremia and reduces virus load in the brain over the course of the infection. These data show that when combined, specific antibody and an interferon inducer can interact synergistically to protect mice from alphavirus infections of the central nervous system even when given after the virus is replicating in the target organ.

Duke Scholars

Published In

Am J Trop Med Hyg

DOI

ISSN

0002-9637

Publication Date

January 1995

Volume

52

Issue

1

Start / End Page

34 / 40

Location

United States

Related Subject Headings

  • Viremia
  • Tropical Medicine
  • Semliki forest virus
  • Polylysine
  • Poly I-C
  • Mice
  • Interferons
  • Interferon Inducers
  • Injections, Intraventricular
  • Injections, Intraperitoneal
 

Citation

APA
Chicago
ICMJE
MLA
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Coppenhaver, D. H., Singh, I. P., Sarzotti, M., Levy, H. B., & Baron, S. (1995). Treatment of intracranial alphavirus infections in mice by a combination of specific antibodies and an interferon inducer. Am J Trop Med Hyg, 52(1), 34–40. https://doi.org/10.4269/ajtmh.1995.52.34
Coppenhaver, D. H., I. P. Singh, M. Sarzotti, H. B. Levy, and S. Baron. “Treatment of intracranial alphavirus infections in mice by a combination of specific antibodies and an interferon inducer.Am J Trop Med Hyg 52, no. 1 (January 1995): 34–40. https://doi.org/10.4269/ajtmh.1995.52.34.
Coppenhaver DH, Singh IP, Sarzotti M, Levy HB, Baron S. Treatment of intracranial alphavirus infections in mice by a combination of specific antibodies and an interferon inducer. Am J Trop Med Hyg. 1995 Jan;52(1):34–40.
Coppenhaver, D. H., et al. “Treatment of intracranial alphavirus infections in mice by a combination of specific antibodies and an interferon inducer.Am J Trop Med Hyg, vol. 52, no. 1, Jan. 1995, pp. 34–40. Pubmed, doi:10.4269/ajtmh.1995.52.34.
Coppenhaver DH, Singh IP, Sarzotti M, Levy HB, Baron S. Treatment of intracranial alphavirus infections in mice by a combination of specific antibodies and an interferon inducer. Am J Trop Med Hyg. 1995 Jan;52(1):34–40.

Published In

Am J Trop Med Hyg

DOI

ISSN

0002-9637

Publication Date

January 1995

Volume

52

Issue

1

Start / End Page

34 / 40

Location

United States

Related Subject Headings

  • Viremia
  • Tropical Medicine
  • Semliki forest virus
  • Polylysine
  • Poly I-C
  • Mice
  • Interferons
  • Interferon Inducers
  • Injections, Intraventricular
  • Injections, Intraperitoneal