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Effects of propranolol on cardiovascular and neuroendocrine responses to mental arithmetic in type A men.

Publication ,  Journal Article
Williams, RB; Lane, JD; Kuhn, CM; Knopes, K; Schanberg, SM
Published in: Neuropsychopharmacology
December 1988

beta-Adrenergic hyperreactivity has been proposed as a pathogenic mechanism of increased coronary risk in Type A individuals. This study compared the effects of propranolol, diazepam, and placebo on cardiovascular and neuroendocrine responses to a stressful cognitive task in six young Type A males. Although diazepam did not differ from placebo, propranolol attenuated heart rate and norepinephrine responses and enhanced cortisol responses to the task. Findings suggest that propranolol has reciprocal effects on the norepinephrine and cortisol components of the "fight-flight" response. Possible central nervous system mechanisms are described.

Duke Scholars

Published In

Neuropsychopharmacology

ISSN

0893-133X

Publication Date

December 1988

Volume

1

Issue

4

Start / End Page

337 / 340

Location

England

Related Subject Headings

  • Vascular Resistance
  • Testosterone
  • Systole
  • Stress, Psychological
  • Regional Blood Flow
  • Reference Values
  • Psychiatry
  • Propranolol
  • Prolactin
  • Norepinephrine
 

Citation

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ICMJE
MLA
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Williams, R. B., Lane, J. D., Kuhn, C. M., Knopes, K., & Schanberg, S. M. (1988). Effects of propranolol on cardiovascular and neuroendocrine responses to mental arithmetic in type A men. Neuropsychopharmacology, 1(4), 337–340.
Williams, R. B., J. D. Lane, C. M. Kuhn, K. Knopes, and S. M. Schanberg. “Effects of propranolol on cardiovascular and neuroendocrine responses to mental arithmetic in type A men.Neuropsychopharmacology 1, no. 4 (December 1988): 337–40.
Williams RB, Lane JD, Kuhn CM, Knopes K, Schanberg SM. Effects of propranolol on cardiovascular and neuroendocrine responses to mental arithmetic in type A men. Neuropsychopharmacology. 1988 Dec;1(4):337–40.
Williams, R. B., et al. “Effects of propranolol on cardiovascular and neuroendocrine responses to mental arithmetic in type A men.Neuropsychopharmacology, vol. 1, no. 4, Dec. 1988, pp. 337–40.
Williams RB, Lane JD, Kuhn CM, Knopes K, Schanberg SM. Effects of propranolol on cardiovascular and neuroendocrine responses to mental arithmetic in type A men. Neuropsychopharmacology. 1988 Dec;1(4):337–340.
Journal cover image

Published In

Neuropsychopharmacology

ISSN

0893-133X

Publication Date

December 1988

Volume

1

Issue

4

Start / End Page

337 / 340

Location

England

Related Subject Headings

  • Vascular Resistance
  • Testosterone
  • Systole
  • Stress, Psychological
  • Regional Blood Flow
  • Reference Values
  • Psychiatry
  • Propranolol
  • Prolactin
  • Norepinephrine