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Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters

Publication ,  Journal Article
Kiser, PF; Thomas, AA; Eichenbaum, GM; Needham, D; Kim, I
Published in: American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
March 1, 2000

The synthesis and testing of the first symmetrical based on vinylic oligomers of α-hydroxy acids are described. Biodegradable gel networks with chemically defined crosslinks were made and studied and were shown to degrade at a defined rate in response to the environment in which they are bathed. The degradation rate of gels composed of the crosslinkers conform to the known order of importance of steric and electronic effects in ester hydrolysis, as well as the concentration of acid or base. The advantages of the crosslinkers over related technologies are discussed. The oligomers were characterized by nuclear magnetic resonance (NMR) spectroscopy.

Duke Scholars

Published In

American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

ISSN

0032-3934

Publication Date

March 1, 2000

Volume

41

Issue

1

Start / End Page

712 / 713

Related Subject Headings

  • Polymers
  • 3403 Macromolecular and materials chemistry
  • 1007 Nanotechnology
  • 0912 Materials Engineering
  • 0303 Macromolecular and Materials Chemistry
 

Citation

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Kiser, P. F., Thomas, A. A., Eichenbaum, G. M., Needham, D., & Kim, I. (2000). Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters. American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, 41(1), 712–713.
Kiser, P. F., A. A. Thomas, G. M. Eichenbaum, D. Needham, and I. Kim. “Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters.” American Chemical Society, Polymer Preprints, Division of Polymer Chemistry 41, no. 1 (March 1, 2000): 712–13.
Kiser PF, Thomas AA, Eichenbaum GM, Needham D, Kim I. Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters. American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 2000 Mar 1;41(1):712–3.
Kiser, P. F., et al. “Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters.” American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, vol. 41, no. 1, Mar. 2000, pp. 712–13.
Kiser PF, Thomas AA, Eichenbaum GM, Needham D, Kim I. Design and performance of poly(HPMA) hydrogels containing symmetrical biodegradable crosslinkers composed of oligo-lactate and oligo-glycolate esters. American Chemical Society, Polymer Preprints, Division of Polymer Chemistry. 2000 Mar 1;41(1):712–713.

Published In

American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

ISSN

0032-3934

Publication Date

March 1, 2000

Volume

41

Issue

1

Start / End Page

712 / 713

Related Subject Headings

  • Polymers
  • 3403 Macromolecular and materials chemistry
  • 1007 Nanotechnology
  • 0912 Materials Engineering
  • 0303 Macromolecular and Materials Chemistry