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Oligo-α-hydroxy ester cross-linkers: Impact of cross-linker structure on biodegradable hydrogel networks

Publication ,  Journal Article
Eichenbaum, KD; Thomas, AA; Eichenbaum, GM; Gibney, BR; Needham, D; Kiser, PF
Published in: Macromolecules
December 27, 2005

We describe the synthesis of a series of biodegradable oligo-α-hydroxy ester cross-linkers and evaluate their impact on the degradation kinetics and macromolecule diffusion from a hydrogel network. By changing the steric and electronic environment at the site of degradation in the cross-linker, we were able to modulate the degradation, swelling kinetics, and corresponding release profiles of macromolecules from poly(HPMA) hydrogel networks under physiologically relevant conditions. As the steric hindrance and electron demand at the site of hydrolysis for three different cross-linkers was increased, the total time for the hydrogel network to completely dissolve increased from 2 to over 30 days while incubated in pH 7 buffer. As the number of hydrolyzable sites and the electron demand at the side of hydrolysis decreased, the time to completely dissolve decreased from weeks to several days. Increasing the cross-linking density for one of the degradable cross-linkers (1.5% to 3.0% feed ratio) increased the degradation time by several weeks. Burst release was absent for high molecular weight solutes because the release rate depended on controlled degradation of the polymer network and an increase in average network mesh size. The synthetically adaptable cross-linkers described herein offer a new approach for controlling the rate and extent of release from biodegradable hydrogel networks. © 2005 American Chemical Society.

Duke Scholars

Published In

Macromolecules

DOI

ISSN

0024-9297

Publication Date

December 27, 2005

Volume

38

Issue

26

Start / End Page

10757 / 10762

Related Subject Headings

  • Polymers
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
 

Citation

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MLA
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Eichenbaum, K. D., Thomas, A. A., Eichenbaum, G. M., Gibney, B. R., Needham, D., & Kiser, P. F. (2005). Oligo-α-hydroxy ester cross-linkers: Impact of cross-linker structure on biodegradable hydrogel networks. Macromolecules, 38(26), 10757–10762. https://doi.org/10.1021/ma0518306
Eichenbaum, K. D., A. A. Thomas, G. M. Eichenbaum, B. R. Gibney, D. Needham, and P. F. Kiser. “Oligo-α-hydroxy ester cross-linkers: Impact of cross-linker structure on biodegradable hydrogel networks.” Macromolecules 38, no. 26 (December 27, 2005): 10757–62. https://doi.org/10.1021/ma0518306.
Eichenbaum KD, Thomas AA, Eichenbaum GM, Gibney BR, Needham D, Kiser PF. Oligo-α-hydroxy ester cross-linkers: Impact of cross-linker structure on biodegradable hydrogel networks. Macromolecules. 2005 Dec 27;38(26):10757–62.
Eichenbaum, K. D., et al. “Oligo-α-hydroxy ester cross-linkers: Impact of cross-linker structure on biodegradable hydrogel networks.” Macromolecules, vol. 38, no. 26, Dec. 2005, pp. 10757–62. Scopus, doi:10.1021/ma0518306.
Eichenbaum KD, Thomas AA, Eichenbaum GM, Gibney BR, Needham D, Kiser PF. Oligo-α-hydroxy ester cross-linkers: Impact of cross-linker structure on biodegradable hydrogel networks. Macromolecules. 2005 Dec 27;38(26):10757–10762.
Journal cover image

Published In

Macromolecules

DOI

ISSN

0024-9297

Publication Date

December 27, 2005

Volume

38

Issue

26

Start / End Page

10757 / 10762

Related Subject Headings

  • Polymers
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences